Low density lipoprotein (LDL), atherosclerosis and antioxidants

被引：0

作者：

Ryu B.H. ^{[1
]}

机构：

[1] Department of Food Science and Biotechnology, Kyungsung University

来源：

Biotechnology and Bioprocess Engineering | 2000年 / 5卷 / 5期

关键词：

Antioxidant; Atherosclerosis; Low density lipoprotein (LDL);

D O I：

10.1007/BF02942205

中图分类号：

学科分类号：

摘要：

A crucial and causative role in the pathogenesis of atherosclerosis is believed to be the oxidative modification of low density lipoprotein (LDL). The oxidation of LDL involves released free radical driven lipid peroxidation. Several lines of evidence support the role of oxidized LDL in atherogenesis. Epidemiologic studies have demonstrated an association between an increased intake of dietary antioxidant vitamins, such as vitamin E and vitamin C and reduced morbidity and mortality from coronary artery diseases. It is thus hypothesized that dietary antioxidants may help prevent the development and progression of atherosclerosis. The oxidation of LDL has been shown to be reduced by antioxidants, and, in animal models, improved antioxidants may offer possibilities for the prevention of atherosclerosis. The results of several on going long randomized intervention trials will provide valuable information on the efficacy and safety of improved antioxidants in the prevention of atherosclerosis. This review a evaluates current literature involving antioxidants and vascular disease, with a particular focus on the potential mechanisms.

引用

页码：313 / 319

页数：6

共 37 条

[1]

Havel R.J., Eder H.A., Bragdon J.H., The distribution and chemical composition of ultracentrifuglly separated lipoproteins in human serum, J. Clin. Invest., 34, pp. 1345-1535, (1995)

[2]

Stenbrecher U.P., Zhang H., Lougheed M., Role of oxidatively modified LDL in atherosclerosis, Free Radic. Biol. Med., 9, (1990)

[3]

Steinverg D., Parthasarathy S., Carew T.E., Khoo J.C., Wiztum J.L., Beyond cholesterol: Modifications of low density lipoprotein that increases its atherogenicity, N. Engl. J. Med., 320, pp. 915-924, (1989)

[4]

Wiztum J.L., Steinverg D., Role of oxidized low density lipoprotein in atherogenesis, J. Clin. Invest., 88, pp. 1985-11972, (1991)

[5]

Steinvrecher U.P., Zhang H., Lougheed M., Role of oxidatively modified LDL in atherosclerosis, Free Radic. Bile. Med., 9, pp. 155-168, (1990)

[6]

Renaud D., De Lorgiril M., Wine, alcohol, platelets, and the French Paradox for coronary heart disease, Lancet, 339, pp. 1523-1525, (1992)

[7]

Yla-Hertuala S., Palinski W., Rosenfeld M.E., Parhasrathy S., Carew T.E., Butler S., Wiztum J.L., Steinberg D., Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man, J. Clin. Invest., 84, pp. 1086-1095, (1989)

[8]

Esterbauer H., Gebiki J., Puhl H., Jurgens G., The role of lipid peroxidation and antioxidants in oxidative modification of LDL, Free Radic. Biol. Med., 13, pp. 341-390, (1992)

[9]

Jiaial I., Grundy S.M., The effect of dietary supplementation with alpha-tocopherol in the oxidative modification of LDL, J. Lipid Res., 33, pp. 889-906, (1992)

[10]

Verlangieri A.J., Kapeghian J.C., El-Dean S., Bush M., Fruit and vegetable consumption and cardio-vascular disease mortality, Med. Hypotheses, 16, pp. 7-15, (1985)

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