Preparation of a porous chitosan/fibroin-hydroxyapatite composite matrix for tissue engineering

被引:0
作者
Hong Sung Kim
Jong Tae Kim
Young Jin Jung
Su Chak Ryu
Hong Joo Son
Yong Gyun Kim
机构
[1] Pusan National University,Department of Biomaterials Engineering, College of Natural Resources & Life Science
[2] Pusan National University,Joint Research Center of PNU
[3] Pusan National University,Fraunhofer IGB
[4] Pusan National University,Department of Nanomaterials, College of Nano Science and Technology
来源
Macromolecular Research | 2007年 / 15卷
关键词
chitosan; fibroin; hydroxyapatite; composite; porous matrix; pore morphology;
D O I
暂无
中图分类号
学科分类号
摘要
Chitosan, fibroin, and hydroxyapatite are natural biopolymers and bioceramics that are biocompatible, biodegradable, and resorbable for biomedical applications. The highly porous, chitosan-based, bioceramic hybrid composite, chitosan/fibroin-hydroxyapatite composite, was prepared by a novel method using thermally induced phase separation. The composite had a porosity of more than 94% and exhibited two continuous and different morphologies: an irregularly isotropic pore structure on the surface and a regularly anisotropic multilayered structure in the interior. In addition, the composite was composed of an interconnected open pore structure with a pore size below a few hundred microns. The chemical composition, pore morphology, microstructure, fluid absorptivity, protein permeability, and mechanical strength were investigated according to the composition rate of bioceramics to biopolymers for use in tissue engineering. The incorporation of hydroxyapatite improved the fluid absorptivity, protein permeability, and tenacity of the composite while maintaining high porosity and a suitable microstructure.
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页码:65 / 73
页数:8
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