共 747 条
[21]
Adamson PC(2007)Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption Cancer Res 67 7308-455
[22]
Lupo PJ(2019)Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma J Clin Oncol 37 1424-197
[23]
Mody R(2019)Pazopanib in relapsed osteosarcoma patients: report on 15 cases Acta Oncol 58 124-106
[24]
DuBois SG(2020)Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial Lancet Oncol 21 446-2454
[25]
Parsons DW(2013)Tumor infiltrating PD1-positive lymphocytes and the expression of PD-L1 predict poor prognosis of soft tissue sarcomas PLoS One 8 e82870-1370
[26]
Khanna C(2015)The role of programmed cell death-1 (PD-1) and its ligands in pediatric cancer Pediatr Blood Cancer 62 190-1696
[27]
Lau C(2015)Enhanced T-cell immunity to osteosarcoma through antibody blockade of PD-1/PD-L1 interactions J Immunother 38 96-429
[28]
Hawkins DS(2012)Safety, activity, and immune correlates of anti-PD-1 antibody in cancer N Engl J Med 366 2443-4644
[29]
Randall RL(2015)Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma J Immunother Cancer 3 21-171
[30]
Smith M(2015)Increased CTLA-4(+) T cells and an increased ratio of monocytes with loss of class II (CD14(+) HLA-DR(lo/neg)) found in aggressive pediatric sarcoma patients J Immunother Cancer 3 35-3046