End-tidal carbon dioxide levels during resuscitation and carbon dioxide levels in the immediate neonatal period and intraventricular haemorrhage

被引：0
作者：
Kentaro Tamura
Emma E Williams
Theodore Dassios
Anoop Pahuja
Katie A Hunt
Vadivelam Murthy
Prashanth Bhat
Ravindra Bhat
Anthony Milner
Anne Greenough
机构：
[1] Faculty of Life Sciences and Medicine,Women and Children’s Health, School of Life Course Sciences
[2] King’s College London,Division of Neonatology, Maternal and Perinatal Centre
[3] Toyama University Hospital,Neonatal Intensive Care Centre
[4] King’s College Hospital NHS Foundation Trust,The Asthma UK Centre in Allergic Mechanisms of Asthma
[5] Kings College London,undefined
[6] NIHR Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College,undefined
来源：
European Journal of Pediatrics | 2020年 / 179卷
关键词：
Carbon dioxide; End-tidal carbon dioxide; Intraventricular haemorrhage; Prematurity; Resuscitation;
D O I：
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中图分类号：
学科分类号：
摘要：
Abnormal levels of end-tidal carbon dioxide (EtCO2) during resuscitation in the delivery suite are associated with intraventricular haemorrhage (IVH) development. Our aim was to determine whether carbon dioxide (CO2) levels in the first 3 days after birth reflected abnormal EtCO2 levels in the delivery suite, and hence, a prolonged rather than an early insult resulted in IVH. In addition, we determined if greater EtCO2level fluctuations during resuscitation occurred in infants who developed IVH. EtCO2 levels during delivery suite resuscitation and CO2 levels on the neonatal unit were evaluated in 58 infants (median gestational age 27.3 weeks). Delta EtCO2 was the difference between the highest and lowest level of EtCO2. Thirteen infants developed a grade 3–4 IVH (severe group). There were no significant differences in CO2 levels between those who did and did not develop an IVH (or severe IVH) on the NICU. The delta EtCO2 during resuscitation differed between infants with any IVH (6.2 (5.4–7.5) kPa) or no IVH (3.8 (2.7–4.3) kPA) (p < 0.001) after adjusting for differences in gestational age. Delta EtCO2 levels gave an area under the ROC curve of 0.940 for prediction of IVH.
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页码：555 / 559
页数：4
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