Synthesis of 2-(3,3-dimethyl-3,4-dihydroisoquinol-1-yl)propanoic acid amides and their influence on blood coagulation

被引：0
|
作者：
E. S. Limanskii
N. N. Polygalova
B. Ya. Syropyatov
A. G. Mikhailovskii
M. I. Vakhrin
机构：
[1] Perm State Pharmaceutical Academy,
来源：
Pharmaceutical Chemistry Journal | 2009年 / 43卷
关键词：
2-(3,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-1-idene)ethanamides; iodomethylation; 2-(3,3-dimethyl-3,4-dihydroisoquinol-1-yl)propanoic acid amides; influence on blood coagulation; hemostatics; acceleration of blood coagulation time by 14–16%;
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摘要：
A series of new 2-(3,3-dimethyl-3,4-dihydroisoquinol-1-yl)propanoic acid amides have been synthesized using the reaction of methyliodide with 2-(3,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-1-idene)ethanamides that proceeds on the β-atom of the enamine fragment to form iodides of 2-(isoquinol-1-yl)propanoic acid derivatives. Investigation of the influence of the synthesized compounds on blood coagulation showed that all of them are hemostatics. The most active compounds possess radicals such as morpholine and 2-(3,4-dimethoxyphenyl)ethylamine, are not substituted at the amide fragment, and decrease the blood coagulation time by 14–16%.
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页码：89 / 91
页数：2
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