Fontan Liver Disease: Review of an Emerging Epidemic and Management Options

被引:29
作者
Bradley E. [1 ,2 ]
Hendrickson B. [1 ,2 ]
Daniels C. [1 ,2 ]
机构
[1] Department of Internal Medicine, Division of Cardiovascular Medicine, Ohio State University, Columbus, OH
[2] Division Cardiovascular Medicine, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, 43205, OH
关键词
Cirrhosis; Fontan; Liver disease; Single ventricle;
D O I
10.1007/s11936-015-0412-z
中图分类号
学科分类号
摘要
Adults with complex congenital heart disease that resulted in a Fontan procedure frequently experience late cardiac failure. Increasingly, liver disease is recognized as an important complication of single-ventricle anatomy and Fontan physiology; however, there is no consensus regarding liver evaluation in this population. Here, we review what is known about liver disease in this unique group and propose screening and prevention measures. We also review controversial treatment areas including assist devices and transplantation, with a review of outcomes in isolated heart and combined heart-liver transplant. © 2015, Springer Science+Business Media New York.
引用
收藏
页数:15
相关论文
共 83 条
[31]  
Kutty S.S., Peng Q., Danford D.A., Fletcher S.E., Perry D., Talmon G.A., Scott C., Kuger J.D., Dunca K.F., Quiros-Tejeira R.E., Kutty S., Increased hepatic stiffness as consequence of high hepatic afterload in the Fontan circulation: a vascular Doppler and elastography study, Hepatology, pp. 251-260, (2014)
[32]  
Ofei S.Y., Gariepy C., Hanje J., Sisk T., Daniels C.J., Zaidi A.N., Liver fibrosis in adults with Fontan palliation: do common screening studies predict disease severity?, Int J Cardiol, 181, pp. 174-1745, (2015)
[33]  
Suraj S.D., Wallihan D.B., Venkatesh S.K., Ehman R.L., Campbell K.M., Sticka J., Et al., Magnetic resonance elastography of the liver in patients status-post Fontan procedure, Feasib Prelim Res, 9, pp. 7-14, (2014)
[34]  
Wallihan D.B., Podberesky D.J., Marino B.S., Sticka J.S., Suraj S., Relationship of MR elastography determined liver stiffness with cardiac function after Fontan palliation, J Mag Resonance Imag, 40, pp. 1328-1335, (2014)
[35]  
Won Yoo B., Choi J.Y., Eun L.Y., Park H.K., Park Y.H., Kim S.U., Congestive hepatopathy after Fontan operation and related factors assessed by transient elastography, J Thorac Cardiovasc Surg, 148, pp. 1498-1505, (2014)
[36]  
Wu F.M., Opotowsky A.R., Raza R., Harney S., Ukomadu C., Landzberg M.J., Et al., Transient elastography may identify Fontan patients with unfavorable hemodynamics and advanced hepatic fibrosis, Congenit Heart Dis, 9, pp. 438-447, (2014)
[37]  
Wu F.M., Jonas M.M., Opotowsky A.R., Harmon A., Raza R., Ukomadu C., Et al., Portal and centrilobular hepatic fibrosis in Fontan circulation and clinical outcomes, J Heart Lung Transplant, 34, pp. 883-891, (2015)
[38]  
Moyer V.A., Screening for hepatitis C virus infection in adults: U.S. Preventive Services Task Force Recommendation Statement, Ann Intern Med, 159, pp. 349-357, (2013)
[39]  
Lok A.S.F., McMahon B.J., Chronic hepatitis B, Hepatology, 45, pp. 507-539, (2007)
[40]  
Cox D.A., Ginde S., Tweddell J.S., Earing M.G., Outcomes of a hepatitis C screening protocol in at-risk adults with prior cardiac surgery, World J Pediatr Congenit Heart Surg, 4, pp. 503-506, (2014)