Gene editing and its applications in biomedicine

被引：0

作者：

Guanglei Li

Xiangyang Li

Songkuan Zhuang

Liren Wang

Yifan Zhu

Yangcan Chen

Wen Sun

Zeguang Wu

Zhuo Zhou

Jia Chen

Xingxu Huang

Jin Wang

Dali Li

Wei Li

Haoyi Wang

Wensheng Wei

机构：

[1] ShanghaiTech University,School of Life Science and Technology

[2] Shenzhen Second People’s Hospital,Department of Clinical Laboratory, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University

[3] East China Normal University,Shanghai Frontiers Science Research Base of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences

[4] Chinese Academy of Sciences,State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology

[5] University of Chinese Academy of Sciences,Institute for Stem Cell and Regenerative Medicine

[6] Chinese Academy of Sciences,Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking

[7] Peking University,Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences

[8] ShanghaiTech University,Gene Editing Center, School of Life Science and Technology

[9] Bejing Institute for Stem Cell and Regenerative Medicine,HIT Center for Life Sciences

[10] Harbin Institute of Technology,undefined

来源：

Science China Life Sciences | 2022年 / 65卷

关键词：

gene editing; CRISPR; high-throughput functional genomics; diagnostics; animal model; therapeutics;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The steady progress in genome editing, especially genome editing based on the use of clustered regularly interspaced short palindromic repeats (CRISPR) and programmable nucleases to make precise modifications to genetic material, has provided enormous opportunities to advance biomedical research and promote human health. The application of these technologies in basic biomedical research has yielded significant advances in identifying and studying key molecular targets relevant to human diseases and their treatment. The clinical translation of genome editing techniques offers unprecedented biomedical engineering capabilities in the diagnosis, prevention, and treatment of disease or disability. Here, we provide a general summary of emerging biomedical applications of genome editing, including open challenges. We also summarize the tools of genome editing and the insights derived from their applications, hoping to accelerate new discoveries and therapies in biomedicine.

引用

页码：660 / 700

页数：40

共 3599 条

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