Prevalence of low cortisol values in term and near-term infants with vasopressor-resistant hypotension

被引：62

作者：

Fernandez E. ^{[1
]}

Schrader R. ^{[2
]}

Watterberg K. ^{[1
]}

机构：

[1] Department of Pediatrics/Neonatology, The University of New Mexico, Health Sciences Center, Albuquerque

[2] Department of Mathematics/Statistics, The University of New Mexico, Albuquerque

来源：

Journal of Perinatology | 2005年 / 25卷 / 2期

关键词：

D O I：

10.1038/sj.jp.7211211

中图分类号：

学科分类号：

摘要：

Objective: To determine the prevalence of low cortisol values and to evaluate clinical responses to hydrocortisone in ill term and near-term newborns. Study Design: Retrospective cohort study including infants ≥35 weeks gestational age who were mechanically ventilated, received vasopressor therapy, and had a cortisol concentration obtained for evaluation of vasopressor-resistant hypotension. In those infants treated with hydrocortisone, physiologic responses were evaluated and correlated with cortisol values (< 15 vs ≥ 15 μg/dl). Results: A total of 32 infants had cortisol values obtained; 18 (56%) were < 15 μg/dl. In all, 21 infants were treated with hydrocortisone of whom 13 had cortisol values < 15 μg/dl. These 13 infants showed decreased heart rate, dopamine support and fluid bolus requirements after treatment, compared to infants with values ≥ 15 μg/dl (n = 8). Conclusions: A significant number of hypotensive, mechanically ventilated infants have evidence of inadequate adrenal function. Hydrocortisone therapy resulted in hemodynamic stabilization in this population. © 2005 Nature Publishing Group All rights reserved.

引用

页码：114 / 118

页数：4

共 30 条

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