Fragments of the protein α-synuclein, which accumulates in substantia nigra neurons in Parkinson disease, are expressed on the surface of these substantia nigra neurons and induce a form of autoimmunity that could account for the degeneration of these cells in the disease.
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Sulzer D(2017)T cells from patients with Parkinson's disease recognize α-synuclein peptides Nature 546 656-661