Determination of in vivo rat muscle Gd-DTPA relaxivity at 6.3 T

被引:0
作者
T. H. Rozijn
B. P. J. van der Sanden
A. Heerschap
J. H. N. Creyghton
W. M. M. J. Bovee
机构
[1] Delft University of Technology,Department of Applied Physics
[2] Academic Hospital St. Radboud,Department of Radiology
来源
Magnetic Resonance Materials in Physics, Biology and Medicine | 1999年 / 9卷
关键词
Relaxivity; Permeability; Contrast agents; Rat muscle;
D O I
暂无
中图分类号
学科分类号
摘要
For the in vivo relaxivity of Gd-DTPA at 6.3 T in rat muscle a value of 2.7±0.5 (mM s)−1 was found, and for the in vitro value in water 3.00±0.56 (mM s)−1 at 37°C. The temperature dependence of the in vitro relaxivity was −0.087 (mM s °C)−1. The relation between1/T1 and the tissue Gd-DTPA concentration is linear for the normally used in vivo Gd-DTPA concentration range
引用
收藏
页码:65 / 71
页数:6
相关论文
共 90 条
[1]  
Rozijn TH(1998)Influence of the pharmacokinetic model on the quantification of the Gd-DTPA uptake rate in brain tumours using direct Magn Reson Mater 6 37-43
[2]  
van der Sanden BPJ(1998) measurements Magn Reson Mater 6 58-58
[3]  
Heerschap A(1998)Gd-DTPA uptake rates are linearly related to the perfused capillary surface-area in 9L gliomas rat models Radiology 207 791-7
[4]  
Creyghton JHN(1996)Evaluation of chemotherapy in advanced urinary bladder cancer with fast dynamic contrast-enhanced MR imaging J Magn Reson Imaging 1 195-202
[5]  
Bovée WMMJ(1994)Angiogenic response of MCF7 human breast cancer to hormonal treatment: assessment by dynamic Gd-DTPA enhanced MRI at high spatial resolution Magn Reson Med 31 292-301
[6]  
van der Sanden BPJ(1984)Quantitative MRI of Gd-DTPA uptake in tumors: response to photodynamic therapy Magn Reson Med 1 496-501
[7]  
Rozijn TH(1986)Magnetic field dependence of solvent proton relaxation induced by Gd Magn Reson Med 3 242-50
[8]  
Rijken P(1985) and Mn J Comput Assist Tomogr 9 242-51
[9]  
Peters H(1985) complexes Radiology 154 723-6
[10]  
Heerschap A(1991)Magnetic field dependence of solvent proton relaxation rates induced by Gd Magn Reson Med 22 191-4