GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus

被引：0

作者：

Patrick Sleiman

Dai Wang

Joseph Glessner

Dexter Hadley

Raquel E. Gur

Nadine Cohen

Qingqin Li

Hakon Hakonarson

机构：

[1] The Center for Applied Genomics,Department of Pediatrics

[2] The Children's Hospital of Philadelphia,Department of Psychiatry

[3] Philadelphia,undefined

[4] PA,undefined

[5] 19104,undefined

[6] USA,undefined

[7] University of Pennsylvania School of Medicine,undefined

[8] Philadelphia,undefined

[9] PA,undefined

[10] 19104,undefined

[11] USA,undefined

[12] Perelman School of Medicine,undefined

[13] University of Pennsylvania,undefined

[14] Janssen Research & Development,undefined

[15] LLC,undefined

[16] Janssen Scientific Affairs,undefined

[17] LLC,undefined

[18] Titusville,undefined

[19] New Jersey,undefined

[20] USA,undefined

来源：

Scientific Reports | / 3卷

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摘要：

We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel locus at chr8q24.3, encompassing TSNARE1 (P = 1.28 × 10−9). The analysis included a total of 13,394 cases and 34,676 controls. While the function of TSNARE1 remains unknown, bioinformatic predictions based on phylogenetic ancestry indicate it may have a vertebrate-specific function in intracellular protein transport and synaptic vesicle exocytosis.

引用

共 42 条

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