Iatrogenic hypervitaminosis D as an unusual cause of persistent vomiting: A case report

被引:14
作者
Bansal R.K. [1 ]
Tyagi P. [1 ]
Sharma P. [1 ]
Singla V. [1 ]
Arora V. [1 ]
Bansal N. [1 ]
Kumar A. [1 ]
Arora A. [1 ]
机构
[1] Department of Gastroenterology and Hepatology, Sir Ganga Ram Hospital, New Delhi 110 060, Rajinder Nagar
关键词
Hypercalcemia; Hypervitaminosis; Vitamin D;
D O I
10.1186/1752-1947-8-74
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摘要
Introduction. Vitamin D is increasingly recognized to have several beneficial effects. Vitamin D deficiency is widely prevalent. Physicians often treat patients with high doses of vitamin D for various ailments without any monitoring for adverse effects and the prescribed doses often far exceed requirements resulting in toxicity. We present here a classic case of iatrogenic hypervitaminosis D, which presented with persistent vomiting and acute renal failure. Case presentation. Here we present a case of a 45-year-old Asian Indian woman who presented to us with persistent vomiting the cause of which was iatrogenic hypervitaminosis D. She was treated with intravenous fluid, diuretics and calcitonin and had clinical improvement. Conclusions: We suggest that in any patient presenting with persistent vomiting and hypercalcemia, particularly in the presence of normal parathyroid hormone, a diagnosis of overdose of vitamin D should be suspected. Its treatment not only alleviates symptoms but also prevents ongoing acute kidney injury. © 2014 Bansal et al.; licensee BioMed Central Ltd.
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共 10 条
[1]  
Robert M.R., Paolo M.S., Vitamin and trace mineral deficiency and excess, Harrison's Principles of Internal Medicine, Volume 1, pp. 594-605, (2012)
[2]  
Hathcock J.N., Shao A., Vieth R., Heaney R., Risk assessment for vitamin D, American Journal of Clinical Nutrition, 85, 1, pp. 6-18, (2007)
[3]  
Christakos S., Ajibade D.V., Dhawan P., Fechner A.J., Mady L.J., Vitamin D: Metabolism, Endocrinol Metab Clin North Am, 39, 2, pp. 243-253, (2010)
[4]  
Glade M.J., Vitamin D: Health panacea or false prophet?, Nutrition, 29, 1, pp. 37-41, (2013)
[5]  
John Jr. T.P., Harald J., Disorders of the parathyroid gland and calcium homeostasis, Harrison's Principles of Internal Medicine, Volume 2, pp. 3096-3120, (2012)
[6]  
Jones G., Pharmacokinetics of vitamin D toxicity, Am J Clin Nutr, 88, 2, (2008)
[7]  
Bouillon R., Vitamin D: From photosynthesis, metabolism, and action to clinical application, Endocrinology, pp. 1089-1110, (2010)
[8]  
Maji D., Vitamin D toxicity, Indian J Endocrinol Metab, 16, 2, pp. 295-296, (2012)
[9]  
Pandita K.K., Razdan S., Kudyar R.P., Beigh A., Kuchay S., Banday T., Excess good can be dangerous. A case series of iatrogenic symptomatic hypercalcemia due to hypervitaminosis D, Clin Cases Miner Bone Metab, 9, 2, pp. 118-120, (2012)
[10]  
Koul P.A., Ahmad S.H., Ahmad F., Jan R.A., Shah S.U., Khan U.H., Vitamin d toxicity in adults: A case series from an area with endemic hypovitaminosis d, Oman Med J, 26, 3, pp. 201-204, (2011)