Effects of Neural Crest-Derived Multipotent Stem Cells on Regeneration of an Injured Peripheral Nerve in Mice

被引：0

作者：

R. G. Vasyliev

A. E. Rodnichenko

S. N. Shamalo

A. S. Demidchouk

I. F. Labunets

Yu. B. Chaikovskii

G. M. Butenko

机构：

[1] National Academy of Medical Sciences of Ukraine,State Institute of Genetic and Regenerative Medicine

[2] Ministry of Public Health of Ukraine,Bogomolets National Medical University

来源：

Neurophysiology | 2015年 / 47卷

关键词：

stem cells; peripheral nerve; transplantation; regeneration;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We studied the effect of transplantation of neural crest-derived multipotent stem cells (NC-MSCs) obtained from vibrissa germs on regeneration of the injured (transected) sciatic nerve in adult mice (strain FVB). After transplantation of the cells into the injured region, regeneration of the severed nerve was intensified, as compared with that in mice with no implantation. The intensity of vascularization and renewal of the endoneurium also increased. The density of nerve fibers in the distal part of the injured nerve in mice after transplantation of NC-MSCs (10522.8 ± 1044.0 mm–2) was significantly higher than that in mice with nerve injury but without transplantation (8409.5 ± 739.5 mm–2). Possible mechanisms of acceleration of regeneration of the injured peripheral nerve under conditions of transplantation of stem cells are discussed.

引用

页码：80 / 83

页数：3

共 17 条

[1]

Petrova ES(2012)The use of stem cells for stimulation of regeneration of the damaged nerve Tsitologiya 54 525-540

[2]

Butenko GM(2013)Stem cells and the problem of restoration of peripheral nerves Мustetsvo Likuvannya 101 56-58

[3]

Chaikovskii YB(2005)Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves Proc. Natl. Acad. Sci. USA 102 17734-17738

[4]

Amoh Y(2014) properties of neural crest-derived multipotent stem cells from a bulge region of whisker follicle Biotechnol. Acta 7 71-79

[5]

Li L(1981)Rapid technique for silver nitrate impregnation of elements of the peripheral nerve system, which is suitable for paraffin and celloidin sections Arkh. Anat. 81 93-96

[6]

Campillo R(2010)Schwann cell delivery of neurotrophic factors for peripheral nerve regeneration J. Peripher. Nerv. Syst. 15 93-103

[7]

Vasyliev RG(1989)The bloodnerve barriers in Wallerian degeneration: a sequential long-term study Muscle Nerve 12 627-635

[8]

Rodnichenko AE(undefined)undefined undefined undefined undefined-undefined

[9]

Zubov DA(undefined)undefined undefined undefined undefined-undefined

[10]

Kolomiitsev AK(undefined)undefined undefined undefined undefined-undefined

← 1 2 →