Progress in diagnosis and treatment of Leber’s hereditary optic neuropathy

被引：0
作者：
Qingyue Ma
Ying Sun
Ke Lei
Wenjuan Luo
机构：
[1] The Affiliated Hospital of Qingdao University,Department of Ophthalmology
[2] The Affiliated Qingdao Central Hospital of Qingdao University,Center of Tumor Immunology and Cytotherapy, Medical Research Center
[3] The Second Affiliated Hospital of Medical College of Qingdao University,undefined
[4] The Affiliated Hospital of Qingdao University,undefined
来源：
Journal of Molecular Medicine | 2024年 / 102卷
关键词：
Leber’s hereditary optic neuropathy; mtDNA; Diagnosis; Treatment; Progress;
D O I：
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中图分类号：
学科分类号：
摘要：
Leber’s hereditary optic neuropathy (LHON) is a mitochondrial genetic disease with central vision loss as the main symptom. It is one of the diseases that cause vision loss and optic atrophy in young and middle-aged people. The mutations of these three primary mitochondrial mutations, m.11778G>A, m.14484T>C, and m.3460G>A, are the main molecular basis, but their pathogenesis is also affected by nuclear genes, mitochondrial genetic background, and environmental factors. This article summarizes the research progress on molecular pathogenesis, clinical symptoms, and treatment of LHON in recent years, aiming to summarize the genetic pathogenesis and clinical treatment points of LHON.
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页码：1 / 10
页数：9
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