Complexes of Glucosamine Hydrochloride and Phytic Acid in Aqueous Medium and Their Antioxidant Properties in Human Blood Plasma

被引：0
作者：
N. B. Mel’nikova
M. V. Sidorova
A. R. Sorokina
A. K. Martusevich
S. P. Peretyagin
A. V. Kochubeinik
M. V. Gulenova
A. E. Bol’shakova
机构：
[1] Nizhnii Novgorod State Medical Academy,Nizhnii Novgorod Research Institute of Traumatology and Orthopedics
[2] Ministry of Public Health of the Russian Federation,undefined
来源：
Pharmaceutical Chemistry Journal | 2016年 / 49卷
关键词：
phytic acid; glucosamine hydrochloride; antioxidant activity; superoxide dismutase;
D O I：
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学科分类号：
摘要：
The reaction in aqueous medium of phytic acid (myo-inositol hexakisphosphate) and glucosamine hydrochloride (2-amino-2-deoxy-β-D-glucopyranose hydrochloride) formed phytic acid—glucosamine complexes of formula InsP6 5GA. Their compositions were proved by elemental analysis for C, H, N, and P. IR, PMR, 13C NMR, and 31P NMR spectroscopy and potentiometric titration showed that the complexes of phytic acid and glucosamine were formed by H-bonds and electrostatic salt interactions. High antioxidant activity against lipid peroxidation and a positive effect on superoxide dismutase activity were found for complexes of InsP6H12 and glucosamine in in vitro studies of human blood plasma under oxidative stress.
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页码：667 / 671
页数：4
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