Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase

被引：0
|
作者：
Stephanie M Stanford
Alexander E Aleshin
Vida Zhang
Robert J Ardecky
Michael P Hedrick
Jiwen Zou
Santhi R Ganji
Matthew R Bliss
Fusayo Yamamoto
Andrey A Bobkov
Janna Kiselar
Yingge Liu
Gregory W Cadwell
Shilpi Khare
Jinghua Yu
Antonio Barquilla
Thomas D Y Chung
Tomas Mustelin
Simon Schenk
Laurie A Bankston
Robert C Liddington
Anthony B Pinkerton
Nunzio Bottini
机构：
[1] La Jolla Institute for Allergy and Immunology,Division of Cellular Biology
[2] University of California,Department of Medicine
[3] Infectious and Inflammatory Disease Center,Department of Respiratory
[4] Sanford Burnham Prebys Medical Discovery Institute,Department of Orthopaedic Surgery and Department of Pediatrics
[5] Conrad Prebys Center for Chemical Genomics,undefined
[6] Sanford Burnham Prebys Medical Discovery Institute,undefined
[7] Center for Proteomics and Bioinformatics,undefined
[8] Case Western Reserve University,undefined
[9] Institute for Genetic Medicine,undefined
[10] University of Southern California,undefined
[11] Inflammation and Autoimmunity,undefined
[12] MedImmune LLC,undefined
[13] University of California,undefined
来源：
Nature Chemical Biology | 2017年 / 13卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The generation of low-molecular-weight protein tyrosine phosphatase (LMPTP) knockout mice combined with the identification of a small-molecule uncompetitive LMPTP inhibitor reveals a role for LMPTP in regulating insulin resistance.[graphic not available: see fulltext]
引用
收藏
页码：624 / 632
页数：8
相关论文
共 50 条
  • [1] Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase
    Stanford, Stephanie M.
    Aleshin, Alexander E.
    Zhang, Vida
    Ardecky, Robert J.
    Hedrick, Michael P.
    Zou, Jiwen
    Ganji, Santhi R.
    Bliss, Matthew R.
    Yamamoto, Fusayo
    Bobkov, Andrey A.
    Kiselar, Janna
    Liu, Yingge
    Cadwell, Gregory W.
    Khare, Shilpi
    Yu, Jinghua
    Barquilla, Antonio
    Chung, Thomas D. Y.
    Mustelin, Tomas
    Schenk, Simon
    Bankston, Laurie A.
    Liddington, Robert C.
    Pinkerton, Anthony B.
    Bottini, Nunzio
    NATURE CHEMICAL BIOLOGY, 2017, 13 (06) : 624 - +
  • [2] SOLUTION STRUCTURE OF A LOW-MOLECULAR-WEIGHT PROTEIN-TYROSINE-PHOSPHATASE
    LOGAN, TM
    ZHOU, MM
    NETTESHEIM, DG
    MEADOWS, RP
    VANETTEN, RL
    FESIK, SW
    BIOCHEMISTRY, 1994, 33 (37) : 11087 - 11096
  • [3] Comparative molecular field analysis of protein tyrosine phosphatase low-molecular-weight substrates
    Sulea, T
    Purisima, EO
    THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE, 1998, 434 : 139 - 153
  • [4] Kinetic characterization of bovine lung low-molecular-weight protein tyrosine phosphatase
    Buzalaf, MAR
    Taga, EM
    Granjeiro, JM
    Ferreira, CV
    Lourençao, VA
    Ortega, MM
    Poletto, DW
    Aoyama, H
    EXPERIMENTAL LUNG RESEARCH, 1998, 24 (03) : 269 - 272
  • [5] Computational modeling of catalysis and binding in low-molecular-weight protein tyrosine phosphatase
    Kolmodin, K
    Åqvist, J
    INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, 1999, 73 (02) : 147 - 159
  • [6] Low-molecular-weight protein tyrosine phosphatase and human disease: in search of biochemical mechanisms
    Bottini, N
    Bottini, E
    Gloria-Bottini, F
    Mustelin, T
    ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 2002, 50 (02) : 95 - 104
  • [7] Solution structure of a low-molecular-weight protein tyrosine phosphatase from Bacillus subtilis
    Xu, HM
    Xia, B
    Jin, CW
    JOURNAL OF BACTERIOLOGY, 2006, 188 (04) : 1509 - 1517
  • [8] Weak oligomerization of low-molecular-weight protein tyrosine phosphatase is conserved from mammals to bacteria
    Blobel, Jascha
    Bernado, Pau
    Xu, Huimin
    Jin, Changwen
    Pons, Miquel
    FEBS JOURNAL, 2009, 276 (16) : 4346 - 4357
  • [9] Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism
    He, Rongjun
    Wang, Jifeng
    Yu, Zhi-Hong
    Zhang, Ruo-Yu
    Liu, Sijiu
    Wu, Li
    Zhang, Zhong-Yin
    JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (19) : 9094 - 9106
  • [10] Backbone NMR Assignment of the Low-molecular-weight Protein Tyrosine Phosphatase (MPtpA) from Mycobacterium Tuberculosis
    Krishna Saxena
    Bettina Elshorst
    Holger Berk
    Marco Betz
    Susanne Grimme
    Thomas Langer
    Barbara Pescatore
    Ulrich Schieborr
    Martin Vogtherr
    Harald Schwalbe
    Journal of Biomolecular NMR, 2005, 33 : 136 - 136
12345