Gene expression across mammalian organ development

被引：0

作者：

Margarida Cardoso-Moreira

Jean Halbert

Delphine Valloton

Britta Velten

Chunyan Chen

Yi Shao

Angélica Liechti

Kelly Ascenção

Coralie Rummel

Svetlana Ovchinnikova

Pavel V. Mazin

Ioannis Xenarios

Keith Harshman

Matthew Mort

David N. Cooper

Carmen Sandi

Michael J. Soares

Paula G. Ferreira

Sandra Afonso

Miguel Carneiro

James M. A. Turner

John L. VandeBerg

Amir Fallahshahroudi

Per Jensen

Rüdiger Behr

Steven Lisgo

Susan Lindsay

Philipp Khaitovich

Wolfgang Huber

Julie Baker

Simon Anders

Yong E. Zhang

Henrik Kaessmann

机构：

[1] Center for Molecular Biology of Heidelberg University (ZMBH),Center for Integrative Genomics

[2] University of Lausanne,Genome Biology Unit

[3] European Molecular Biology Laboratory,Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology

[4] Chinese Academy of Sciences,State Key Laboratory of Integrated Management of Pest Insects and Rodents

[5] Institute of Zoology,Center for Neurobiology and Brain Restoration

[6] Chinese Academy of Sciences,Faculty of Computer Science

[7] University of Chinese Academy of Sciences,Institute of Medical Genetics

[8] Skolkovo Institute of Science and Technology,Laboratory of Behavioral Genetics

[9] Institute for Information Transmission Problems (Kharkevich Institute) RAS,Institute for Reproduction and Perinatal Research, Departments of Pathology and Laboratory Medicine and Pediatrics

[10] HSE University,Center for Perinatal Research, Children’s Research Institute

[11] Cardiff University,Departamento de Anatomia

[12] Brain Mind Institute,ICBAS (Instituto de Ciências Biomédicas Abel Salazar), UMIB (Unidade Multidisciplinar de Investigação Biomédica)

[13] École Polytechnique Fédérale de Lausanne (EPFL),CIBIO/InBIO, Centro de Investigacão em Biodiversidade e Recursos Genéticos

[14] University of Kansas Medical Center,Departamento de Biologia, Faculdade de Ciências

[15] Children’s Mercy,Sex Chromosome Biology Laboratory

[16] Universidade do Porto,South Texas Diabetes and Obesity Institute, School of Medicine

[17] Universidade do Porto,The Department of Human Genetics, School of Medicine

[18] Universidade do Porto,AVIAN Behavioural Genomics and Physiology Group, IFM Biology

[19] Universidade do Porto,Platform Degenerative Diseases, German Primate Center

[20] The Francis Crick Institute,DZHK (German Center for Cardiovascular Research)

[21] The University of Texas Rio Grande Valley,Human Developmental Biology Resource, Institute of Genetic Medicine

[22] Brownsville,Center for Excellence in Animal Evolution and Genetics

[23] The University of Texas Rio Grande Valley,CAS Key Laboratory of Computational Biology, CAS

[24] Brownsville,MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences

[25] Linköping University,Department of Genetics

[26] Leibniz Institute for Primate Research (DPZ),undefined

[27] Partner Site Göttingen,undefined

[28] Newcastle University,undefined

[29] Chinese Academy of Sciences,undefined

[30] University of Chinese Academy of Sciences,undefined

[31] Chinese Academy of Sciences,undefined

[32] Stanford University School of Medicine,undefined

来源：

Nature | 2019年 / 571卷

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摘要：

The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs.

引用

页码：505 / 509

页数：4

共 136 条

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