A new isoflavone derivative from Streptomyces sp. YIM GS3536

被引：0
作者：
Rong Huang
Zhang-Gui Ding
Yun-Feng Long
Jiang-Yuan Zhao
Ming-Gang Li
Xiao-Long Cui
Meng-Liang Wen
机构：
[1] Key Laboratory of Medicinal Chemistry for Natural Resource,Key Laboratory for Microbial Resources, Ministry of Education, Yunnan Institute of Microbiology
[2] Yunnan University,undefined
来源：
Chemistry of Natural Compounds | 2013年 / 48卷
关键词：
7-; -methyl-8-chlorogenistein; sp.; cytotoxicity; antimicrobial activity;
D O I：
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学科分类号：
摘要：
A new natural product named 7-O-methyl-8-chlorogenistein (1) was isolated together with eight known isoflavones, 8-chlorogenistein (2), kakkatin (3), 7-O-methyl genistein (4), genistein (5), daidzein (6), glycitin (7), genistin (8), and daidzin (9), from the metabolites of Streptomyces strain YIM GS3536, which was isolated from soil sample collected from Yunnan Province, China. We report the unambiguous assignments of the 1H and 13C NMR spectra of the new compound 7-O-methyl-8-chlorogenistein (1). Compound 1 exhibited appreciable cytotoxicity against human melanoma cell lines (B16) and human leukemia cell lines (HL60) with IC50 values of 17.5 and 19.2 μM, respectively. The MIC values of 1 for Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Candida albicans were in the range of 23–35 μM.
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页码：966 / 969
页数：3
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