NMR resonance assignment of a fibroblast growth factor 8 splicing isoform b

被引：0
作者：
Bruno Hargittay
Konstantin S. Mineev
Christian Richter
Sridhar Sreeramulu
Hendrik R.A. Jonker
Krishna Saxena
Harald Schwalbe
机构：
[1] Johann Wolfgang Goethe University,Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ)
[2] Johann Wolfgang Goethe University,Structural Genomics Consortium
来源：
Biomolecular NMR Assignments | 2023年 / 17卷
关键词：
Fibroblast growth factor; FGF8b; FGF8; FGF; Structure; Dynamics; Motions; FGFR; Fibroblast growth factor receptor.;
D O I：
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学科分类号：
摘要：
The splicing isoform b of human fibroblast growth factor 8 (FGF8b) is an important regulator of brain embryonic development. Here, we report the almost complete NMR chemical shift assignment of the backbone and aliphatic side chains of FGF8b. Obtained chemical shifts are in good agreement with the previously reported X-ray data, excluding the N-terminal gN helix, which apparently forms only in complex with the receptor. The reported data provide an NMR starting point for the investigation of FGF8b interaction with its receptors and with potential drugs or inhibitors.
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页码：135 / 142
页数：7
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