Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients

被引：0
作者：
Yong Dai
Weiguo Sui
Huijuan Lan
Qiang Yan
He Huang
YuanShuai Huang
机构：
[1] Jinan University,The Second Clinical Medical College
[2] Shenzhen People’s Hospital,Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education
[3] Kidney Transplantation and Hemo Purification Center,undefined
[4] Chongqing Medical University,undefined
来源：
Rheumatology International | 2009年 / 29卷
关键词：
MicroRNA; Microarray; Lupus nephritis; Human;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MicroRNAs (miRNAs) are noncoding RNA molecules of 21–24 nt that regulate the expression of target genes in a post-transcriptional manner. Evidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation, and pathogenesis of human diseases. This study describes a comparison between the miRNA profile of kidney biopsies from lupus nephritis (LN) patients and the controls, to develop further understanding of the pathogenesis of LN. Kidney biopsies were taken from five LN patients detected LN Class II and three normal controls. The miRNA microarray chip analysis identified 66 miRNAs differentially expressed in LN. The chip results were confirmed by QRT-PCR. This work indicates that miRNAs are potential diagnosis biomarkers and probable factors involved in the pathogenesis of LN.
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页码：749 / 754
页数：5
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