Prenatal Androgen Exposure and Traits of Autism Spectrum Disorder in the Offspring: Odense Child Cohort

被引：0

作者：

Camilla V. B. Palm

Dorte Glintborg

Laura G. Find

Pia V. Larsen

Cilia M. Dalgaard

Henriette Boye

Tina K. Jensen

Anja F. Dreyer

Marianne S. Andersen

Niels Bilenberg

机构：

[1] Odense University Hospital,Department of Endocrinology and Metabolism

[2] University of Southern Denmark,Department of Clinical Research, Faculty of Health Sciences

[3] University of Southern Denmark,Department of Child and Adolescent Mental Health Odense, Mental Health Services in the Region of Southern Denmark

[4] Odense Child Cohort,OPEN Patient Data Explorative Network (OPEN)

[5] Hans Christian Andersen Hospital for Children and Adolescents,Department of Environmental Medicine

[6] Odense University Hospital,undefined

[7] University of Southern Denmark,undefined

[8] Odense University Hospital,undefined

[9] Mental Health Services in the Region of Southern Denmark,undefined

[10] University of Southern Denmark,undefined

来源：

Journal of Autism and Developmental Disorders | 2023年 / 53卷

关键词：

Autism spectrum; Prenatal; Testosterone; Birth cohort;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Fetal androgen exposure may be associated with autism spectrum disorder (ASD). We studied 1777 mother–child pairs in the prospective Odense Child Cohort. Prenatal androgen exposure was assessed by maternal 3rd trimester testosterone concentrations, maternal polycystic ovary syndrome (PCOS), and 3 months offspring anogenital distance. ASD traits were assessed at age 3 years with the ASD-symptom scale of the Child Behavior Checklist for ages 1½–5 years. Maternal testosterone was positively associated with traits of ASD in boys (p < 0.05). Maternal PCOS was associated with increased offspring ASD traits (p = 0.046), but became non-significant after excluding parental psychiatric diagnosis. Offspring anogenital distance was not linked to ASD traits. Higher prevalence of ASD in boys could be linked to higher susceptibility to fetal androgen exposure.

引用

页码：1053 / 1065

页数：12

共 377 条

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