Chiral Ligand-Exchange Chromatography for Separation of Three Stereoisomers of Octahydroindole-2-carboxylic Acid

被引：2
|
作者：
Suya Sun
Youzhi Jia
Ning Zeng
Famei Li
机构：
[1] Shenyang Pharmaceutical University,
[2] Shanghai Institute of Pharmaceutical Industry,undefined
来源：
Chromatographia | 2006年 / 63卷
关键词：
Column liquid chromatography; Diastereo-enantio separation; Chiral mobile phase; Ligand-exchange; Octahydroindole-2-carboxylic acid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A novel HPLC method is described for separation of the three stereoisomers of octahydroindole-2-carboxylic acid (Oic), an intermediate in the synthesis of perindopril. The chiral mobile phase contained the complex of Cu(II) with the optically active selector L-phenylalaninamide (L-PheA), and an ion-pair reagent, sodium 1-octanesulfonate. The effects of the concentrations of the Cu(II)–L-PheA complex and the ion-pair reagent, mobile phase pH, ionic strength, acetonitrile content, and column temperature were studied. Satisfactory resolution was achieved for three stereoisomers, RRR-, SSS-, and SRR-Oic.
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页码：331 / 335
页数：4
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