Chiral Ligand-Exchange Chromatography for Separation of Three Stereoisomers of Octahydroindole-2-carboxylic Acid

被引：2

作者：

Suya Sun

Youzhi Jia

Ning Zeng

Famei Li

机构：

[1] Shenyang Pharmaceutical University,

[2] Shanghai Institute of Pharmaceutical Industry,undefined

来源：

Chromatographia | 2006年 / 63卷

关键词：

Column liquid chromatography; Diastereo-enantio separation; Chiral mobile phase; Ligand-exchange; Octahydroindole-2-carboxylic acid;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A novel HPLC method is described for separation of the three stereoisomers of octahydroindole-2-carboxylic acid (Oic), an intermediate in the synthesis of perindopril. The chiral mobile phase contained the complex of Cu(II) with the optically active selector L-phenylalaninamide (L-PheA), and an ion-pair reagent, sodium 1-octanesulfonate. The effects of the concentrations of the Cu(II)–L-PheA complex and the ion-pair reagent, mobile phase pH, ionic strength, acetonitrile content, and column temperature were studied. Satisfactory resolution was achieved for three stereoisomers, RRR-, SSS-, and SRR-Oic.

引用

页码：331 / 335

页数：4

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