TMEM49-related apoptosis and metastasis in ovarian cancer and regulated cell death

被引：0
作者：
Lili Zheng
Lingling Chen
Xuan Zhang
Jingfen Zhan
Jie Chen
机构：
[1] FuJian University of Traditional Chinese Medicine,Department of Gynecology
[2] The Second Hospital of Fuzhou Affiliated to Xiamen University,Department of Gynecology
[3] The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine,undefined
来源：
Molecular and Cellular Biochemistry | 2016年 / 416卷
关键词：
TMEM49; Ovarian cancer; Proliferation; Apoptosis; Invasion;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Ovarian cancer is one of the greatest causes of cancer death in women. The association of TMEM49 and ovarian cancer is poorly defined. Here, we reported that TMEM49 was significantly increased in ovarian tumor tissues compared to ovarian normal tissues. Furthermore, down-regulation of TMEM49 through RNA interference inhibited cell proliferation and arrested G1/S transition in two ovarian cancer cell lines, OVCAR3 and A2780. More importantly, TMEM49 silencing induced cell apoptosis. Additionally, down-regulation of TMEM49 in ovarian cancer notably repressed cell invasion and adhesion. Further gene set enrichment analysis suggested that apoptosis and metastasis up related signal pathways were associated with the TMEM49 expression. Western blot revealed that the expression of Caspase3, Bad, and Bax were increased, while expression of MMP2, KLF10, and CXCL12 were reduced by TMEM49 knockdown. Since expression of TMEM49 seems to be associated with the apoptosis and metastasis up signaling pathways of ovarian cancer, and suppression of its expression can inhibit cancer cell growth and metastasis, TMEM49 may be a potential therapeutic target in human ovarian cancer.
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页码：1 / 9
页数：8
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