Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions

被引:0
|
作者
Jia Zhong
Hua Bai
Zhijie Wang
Jianchun Duan
Wei Zhuang
Di Wang
Rui Wan
Jiachen Xu
Kailun Fei
Zixiao Ma
Xue Zhang
Jie Wang
机构
[1] Chinese Academy of Medical Sciences and Peking Union Medical College,State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital
来源
Frontiers of Medicine | 2023年 / 17卷
关键词
non-small cell lung cancer; driver mutations; treatment strategy; resistant mechanism; immune-checkpoint inhibitors;
D O I
暂无
中图分类号
学科分类号
摘要
With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding the targeted therapeutic options improved the survival and safety. However, responses to these agents are commonly temporary and incomplete. Moreover, even patients with the same oncogenic driver gene can respond diversely to the same agent. Furthermore, the therapeutic role of immune-checkpoint inhibitors (ICIs) in oncogene-driven NSCLC remains unclear. Therefore, this review aimed to classify the management of NSCLC with driver mutations based on the gene subtype, concomitant mutation, and dynamic alternation. Then, we provide an overview of the resistant mechanism of target therapy occurring in targeted alternations (“target-dependent resistance”) and in the parallel and downstream pathways (“target-independent resistance”). Thirdly, we discuss the effectiveness of ICIs for NSCLC with driver mutations and the combined therapeutic approaches that might reverse the immunosuppressive tumor immune microenvironment. Finally, we listed the emerging treatment strategies for the new oncogenic alternations, and proposed the perspective of NSCLC with driver mutations. This review will guide clinicians to design tailored treatments for NSCLC with driver mutations.
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页码:18 / 42
页数:24
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