Delivery systems for theranostics in neurodegenerative diseases

被引：0
作者：
Yan Li
Ruiyuan Liu
Weihong Ji
Yanhui Li
Linying Liu
Xin Zhang
机构：
[1] Chinese Academy of Sciences,State Key Laboratory of Biochemical Engineering, Institute of Process Engineering
[2] University of Chinese Academy of Sciences,undefined
来源：
Nano Research | 2018年 / 11卷
关键词：
neurodegenerative diseases; theranostics; blood-brain barrier; delivery systems;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Neurodegenerative diseases are characterized by progressive nervous system dysfunction, which affects over 90,000 people every year. Although numerous contrast agents and therapeutic drugs are available for the diagnosis and therapy of neurodegenerative diseases, there are several limitations to their application. Particularly, these contrast agents and drugs are restricted from entering into the brain because of the blood-brain barrier, which represents a major bottleneck to efficacious and safe theranostics of neurodegenerative diseases. Nanoparticles can offer impressive improvement in the theranostics of neurodegenerative diseases, as they can effectively deliver contrast agents and drugs to target sites in the central nervous system. In this review, we describe various delivery systems, including lipid nanoparticles, polymeric nanoparticles, inorganic nanoparticles, and exosomes useful for the theranostics of neurodegenerative diseases. Finally, we outline current challenges and our perspectives on the development of delivery systems for theranostics of neurodegenerative diseases.
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页码：5535 / 5555
页数：20
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[1]  
Guo J. L.(2014)Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases Nat. Med. 20 130-138
[2]  
Lee V. M. Y.(2015)Spreading of pathology in neurodegenerative diseases: A focus on human studies Nat. Rev. Neurosci. 16 109-120
[3]  
Brettschneider J.(2013)Nanotechnology-based drug delivery systems for targeting, imaging and diagnosis of neurodegenerative diseases Pharm. Res. 30 2499-2511
[4]  
Del Tredici K.(2004)M.-Y Neurodegenerative diseases: A decade of discoveries paves the way for therapeutic breakthroughs. Nat. Med. 10 1055-1063
[5]  
Lee V. M. Y.(2004)Neurodegenerative diseases and oxidative stress Nat. Rev. Drug Discov. 3 205-214
[6]  
Trojanowski J. Q.(2004)Iron, brain ageing and neurodegenerative disorders Nat. Rev. Neurosci. 5 863-873
[7]  
Pehlivan S. B.(2003)Unfolding the role of protein misfolding in neurodegenerative diseases Nat. Rev. Neurosci. 4 49-60
[8]  
Forman M. S.(2012)Molecular imaging of stem cell transplantation for neurodegenerative diseases Curr. Pharm. Design 18 4426-4440
[9]  
Trojanowski J. Q.(2010)Prion-like transmission of protein aggregates in neurodegenerative diseases Nat. Rev. Mol. Cell Biol. 11 301-307
[10]  
Lee V.(2015)Alzheimer's and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein Science 349 1255555-356
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