Application of d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) in transdermal and topical drug delivery systems (TDDS)

被引:24
作者
Pham C.V. [1 ]
Cho C.-W. [1 ]
机构
[1] College of Pharmacy, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon
关键词
Solubilizer; Topical; TPGS; Transdermal;
D O I
10.1007/s40005-016-0300-x
中图分类号
学科分类号
摘要
d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) is a water-soluble nonionic surfactant, which is prepared from the esterification of Vitamin E succinate with polyethylene glycol 1000. Due to unique amphiphilic structure, TPGS offers many essential properties such as solubilizer, penetration enhancer, stabilizer, emulsifier, antioxidant agent and protection of drug in micelles, which can be used for permeation of drug through skin or deposition of drug in skin. Especially, the applications of TPGS for various systems such as supersaturated system, solid lipid nanoparticles, gels, microemulsions, nanoemulsions and solid dispersions will be discussed in this review. © 2017, The Korean Society of Pharmaceutical Sciences and Technology.
引用
收藏
页码:111 / 121
页数:10
相关论文
共 62 条
[11]  
Constantinides P.P., Tustian A., Kessler D.R., Tocol emulsions for drug solubilization and parenteral delivery, Adv Drug Deliv Rev, 56, pp. 1243-1255, (2004)
[12]  
Crowley M.M., Zhang F., Koleng J.J., McGinity J.W., Stability of polyethylene oxide in matrix tablets prepared by hot-melt extrusion, Biomaterials, 23, pp. 4241-4248, (2002)
[13]  
Date A.A., Desai N., Dixit R., Nagarsenker M., Selfnanoemulsifying drug delivery systems: Formulation insights, applications and advances, Nanomedicine (Lond), 5, pp. 1595-1616, (2010)
[14]  
Davis A.F., Hadgraft J., Effect of supersaturation on membrane transport: 1. Hydrocortisone acetate, Int J Pharm, 76, pp. 1-8, (1991)
[15]  
de Leeuw J., de Vijlder H.C., Bjerring P., Neumann H.A., Liposomes in dermatology today, J Eur Acad Dermatol Venereol, 23, pp. 505-516, (2009)
[16]  
Elsayed M.M., Abdallah O.Y., Naggar V.F., Khalafallah N.M., Lipid vesicles for skin delivery of drugs: reviewing three decades of research, Int J Pharm, 332, pp. 1-16, (2007)
[17]  
Falconer J.R., Wen J., Zargar-Shoshtari S., Chen J.J., Farid M., El Maghraby G.M., Alany R.G., Evaluation of progesterone permeability from supercritical fluid processed dispersion systems, Pharm Dev Technol, 19, pp. 238-246, (2014)
[18]  
Fischer S.M., Flaten G.E., Hagesaether E., Fricker G., Brandl M., In-vitro permeability of poorly water soluble drugs in the phospholipid vesicle-based permeation assay: the influence of nonionic surfactants, J Pharm Pharmacol, 63, pp. 1022-1030, (2011)
[19]  
Ghosh I., Michniak-Kohn B., A comparative study of Vitamin, E TPGS/HPMC supersaturated system and other solubilizer/polymer combinations to enhance the permeability of a poorly soluble drug through the skin. Drug Dev Ind Pharm, 38, pp. 1408-1416, (2012)
[20]  
Ghosh I., Michniak-Kohn B., Design and characterization of submicron formulation for a poorly soluble drug: the effect of Vitamin, E TPGS and other solubilizers on skin permeability enhancement. Int J Pharm, 434, pp. 90-98, (2012)