Dextran-Methylprednisolone Succinate as a Prodrug of Methylprednisolone: Local Immunosuppressive Effects in Liver After Systemic Administration to Rats

被引：0
作者：
Anjaneya P. Chimalakonda
Reza Mehvar
机构：
[1] Texas Tech University Health Sciences Center,School of Pharmacy
来源：
Pharmaceutical Research | 2003年 / 20卷
关键词：
methylprednisolone; dextran prodrugs; local immunosuppression; liver perfusion; hepatic delivery;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The purpose of this work was to study the local immunosuppressive effects of systemically administered methylprednisolone (MP) and its prodrug, dextran-methylprednisolone (DMP), in rat livers.
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页码：198 / 204
页数：6
相关论文
共 104 条
[1]  
Asfar S.(1996)An analysis of late deaths after liver transplantation Transplantation 61 1377-1381
[2]  
Metrakos P.(2000)Immunosuppression in liver transplantation Semin. Liver Dis. 20 523-531
[3]  
Fryer J.(1989)Long-term complications of conventional immunosuppressive treatment Adv. Nephrol. Necker Hosp. 18 335-354
[4]  
Verran D.(1992)The case for local immunosuppression Transplantation 54 1-11
[5]  
Ghent C.(1995)The enhanced immunosuppressive efficacy of newly developed liposomal FK506 in canine liver transplantation Transplantation 59 1384-1388
[6]  
Grant D.(1994)The significance of local immunosuppression in canine liver transplantation Transplantation 57 1818-1821
[7]  
Bloch M.(1997)Local immunosuppression with budesonide after liver transplantation in the rat-A preliminary histomorphological analysis Transplantation 64 705-708
[8]  
Burns P.(1994)Molecular weight dependent tissue accumulation of dextrans: J. Pharm. Sci. 83 1495-1499
[9]  
Wall W.(2001) studies in rats J. Pharm. Sci. 90 2078-2087
[10]  
Cattral M. S.(2000)Dextran-methylprednisolone succinate as a prodrug of methylprednisolone: plasma and tissue disposition Pharm. Res. 17 1402-1407
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