Risk factors for asthma and allergy associated with urban migration: Background and methodology of a cross-sectional study in Afro-Ecuadorian school children in Northeastern Ecuador (Esmeraldas-SCAALA study)

被引：33

作者：

Cooper P.J. ^{[1
,2
]}

Chico M.E. ^{[1
]}

Vaca M.G. ^{[1
]}

Rodriguez A. ^{[1
]}

Alcântara-Neves N.M. ^{[3
]}

Genser B. ^{[4
]}

de Carvalho L.P. ^{[5
]}

Stein R.T. ^{[6
]}

Cruz A.A. ^{[7
]}

Rodrigues L.C. ^{[8
]}

Barreto M.L. ^{[4
]}

机构：

[1] Instituto de Microbiologia, Universidad San Francisco de Quito, Quito

[2] Centre for Infection, St. George's University of London, London

[3] Instituto de Ciências de Saúde, Universidade Federal de Bahia, Salvador

[4] Instituto de Saúde Coletiva, Universidade Federal de Bahia, Bahia

[5] Centro de Pesquisas Gonçalo Moniz, FIOCRUZ, Salvador

[6] Department of Pediatrics, School of Medicine, Pontifica Universidade Católica, Porto Alegre

[7] Centro de Enfermidades Respiratórias, Faculdade de Medicina, Universidade Federal de Bahia, Salvador

[8] London School of Hygiene and Tropical Medicine, London

来源：

BMC Pulmonary Medicine | / 6卷 / 1期

关键词：

Asthma; Environmental Exposure; Allergic Disease; Peak Expiratory Flow Rate; Life Style Factor;

D O I：

10.1186/1471-2466-6-24

中图分类号：

学科分类号：

摘要：

Background: Asthma and allergic diseases are becoming increasingly frequent in children in urban centres of Latin America although the prevalence of allergic disease is still low in rural areas. Understanding better why the prevalence of asthma is greater in urban migrant populations and the role of risk factors such as life style and environmental exposures, may be key to understand what is behind this trend. Methods/design: The Esmeraldas-SCAALA (Social Changes, Asthma and Allergy in Latin America) study consists of cross-sectional and nested case-control studies of school children in rural and urban areas of Esmeraldas Province in Ecuador. The cross-sectional study will investigate risk factors for atopy and allergic disease in rural and migrant urban Afro-Ecuadorian school children and the nested case-control study will examine environmental, biologic and social risk factors for asthma among asthma cases and non-asthmatic controls from the cross-sectional study. Data will be collected through standardised questionnaires, skin prick testing to relevant aeroallergen extracts, stool examinations for parasites, blood sampling (for measurement of IgE, interleukins and other immunological parameters), anthropometric measurements for assessment of nutritional status, exercise testing for assessment of exercise-induced bronchospasm and dust sampling for measurement of household endotoxin and allergen levels. Discussion: The information will be used to identify the factors associated with an increased risk of asthma and allergies in migrant and urbanizing populations, to improve the understanding of the causes of the increase in asthma prevalence and to identify potentially modifiable factors to inform the design of prevention programmes to reduce the risk of allergy in urban populations in Latin America. © 2006 Cooper et al; licensee BioMed Central Ltd.

引用

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