The role of the hormones of the hypothalamo-hypophyseal-adrenocortical system in the analgesic effect of corticotropin-releasing hormone

被引：6

作者：

Bogdanov A.I. ^{[1
]}

Yarushkina N.I. ^{[1
]}

机构：

[1] Laboratory of Experimental Endocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 199034 St. Petersburg

来源：

Neuroscience and Behavioral Physiology | 2007年 / 37卷 / 4期

关键词：

Corticosterone; Corticotropin-releasing hormone; Opiate receptors; Pain sensitivity; Rats;

D O I：

10.1007/s11055-007-0022-7

中图分类号：

学科分类号：

摘要：

Experiments on anesthetized male rats were performed to study the role of the hormones of the hypothalamo-hypophyseal-adrenocortical system (HHACS) in analgesia induced by central or systemic administration of corticoliberin-releasing hormone (CRF). Studies of the contribution of HHACS hormones were performed by blocking HHACS function by administration of hydrocortisone at a pharmacological dose one week before experiments started. Blockade of HHACS function, resulting in the inability of the system to increase hormone levels, resulted in a decrease in the analgesic effect resulting from systemic administration of CRF and completely abolished the analgesic effect after central administration of CRF. These data lead to the conclusion that there are two components involved in increasing the pain sensitivity threshold in response to administration of CRF: 1) a component dependent on HHACS hormones in central and systemic administration of CRF; 2) a component independent of HHACS hormones on systemic administration of CRF. © Springer Science+Business Media, Inc. 2007.

引用

页码：363 / 367

页数：4

共 28 条

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