Controlled Release of Liposomes from Biodegradable Dextran Microspheres: A Novel Delivery Concept

被引:0
作者
Robert J. H. Stenekes
Arjen E. Loebis
Catarina M. Fernandes
Daan J. A. Crommelin
Wim E. Hennink
机构
[1] University of Utrecht,Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS)
[2] OctoPlus B. V.,undefined
[3] OctoPlus B. V.,undefined
[4] PO Box 722,undefined
关键词
controlled release; liposomes; hydrogel; dextran; microspheres;
D O I
10.1023/A:1007526114744
中图分类号
学科分类号
摘要
Purpose. To design liposome-loaded microspheres, which release theliposomes in a time-controlled manner and in intact form.
引用
收藏
页码:664 / 669
页数:5
相关论文
共 112 条
[1]  
Storm G.(1998)Liposomes: quo vadis? Pharm. Sci. Techn. Today 1 19-31
[2]  
Crommelin D. J. A.(1995)Liposome circulation time and tumor targeting: implications for cancer chemotherapy Adv. Drug Deliv. Rev. 16 285-294
[3]  
Gabizon A. A.(1993)Interleukin-2-containing liposomes: interaction of interleukin-2 with liposomal bilayers and preliminary studies on application in cancer vaccines Pharm. Res. 10 1715-1721
[4]  
Bergers J. J.(1995)The preparation of tissue-type plasminogen activator (t-PA) containing liposomes: entrapment efficiency and ultracentrifugation data J. Drug Targeting 3 301-310
[5]  
den Otter W.(1990)Pharmacokinetic study of liposome-encapsulated human interferon-gamma after intravenous and intramuscular injection in mice J. Interferon Res. 10 337-341
[6]  
Dullens H. F. J.(1999)Liposomes containing interferon-gamma as adjuvant in tumor cell vaccines Pharm. Res. 17 42-48
[7]  
Kerkvliet C. T. M.(1992)Kinetics and prophylactic efficacy of increasing dosages of liposome encapsulated chloroquine after intramuscular injection in mice J. Controlled Rel. 20 47-54
[8]  
Crommelin D. J. A.(1993)Biodegradable hydrogels in drug delivery Adv. Drug Deliv. Rev. 11 59-84
[9]  
Heeremans J. L. M.(1996)Controlled release of proteins from dextran hydrogels J. Controlled Rel. 39 47-55
[10]  
Gerritsen H. R.(1997)Degradation and release behavior of dextran-based hydrogels Macromolecules 30 4639-4645