Facile Approach to Synthesize Gold Nanorod@Polyacrylic Acid/Calcium Phosphate Yolk–Shell Nanoparticles for Dual-Mode Imaging and pH/NIR-Responsive Drug Delivery

被引：0
作者：
Guilan Li
Yidan Chen
Lingyu Zhang
Manjie Zhang
Shengnan Li
Lu Li
Tingting Wang
Chungang Wang
机构：
[1] Northeast Normal University,Faculty of Chemistry
[2] Changchun University of Science and Technology,School of Chemistry and Environmental Engineering
来源：
Nano-Micro Letters | 2018年 / 10卷
关键词：
Yolk–shell structure; Calcium phosphate; Dual-mode imaging; Photothermal therapy; Drug delivery;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A facile strategy to fabricate gold nanorod@polyacrylic acid/calcium phosphate (AuNR@PAA/CaP) yolk–shell nanoparticles (NPs) composed with a PAA/CaP shell and an AuNR yolk is reported. The as-obtained AuNR@PAA/CaP yolk–shell NPs possess ultrahigh doxorubicin (DOX) loading capability (1 mg DOX/mg NPs), superior photothermal conversion property (26%) and pH/near-infrared (NIR) dual-responsive drug delivery performance. The released DOX continuously increased due to the damage of the CaP shell at low pH values. When the DOX-loaded AuNR@PAA/CaP yolk–shell NPs were exposed to NIR irradiation, a burst-like drug release occurs owing to the heat produced by the AuNRs. Furthermore, AuNR@PAA/CaP yolk–shell NPs are successfully employed for synergic dual-mode X-ray computed tomography/photoacoustic imaging and chemo-photothermal cancer therapy. Therefore, this work brings new insights for the synthesis of multifunctional nanomaterials and extends theranostic applications.
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