Modeling neurological diseases using iPSC-derived neural cellsiPSC modeling of neurological diseases

被引：0
作者：
Li Li
Jianfei Chao
Yanhong Shi
机构：
[1] Beckman Research Institute of City of Hope,Division of Stem Cell Biology, Department of Developmental and Stem Cell Biology
[2] Beckman Research Institute of City of Hope,Irell and Manella Graduate School of Biological Sciences
来源：
Cell and Tissue Research | 2018年 / 371卷
关键词：
iPSC; Neurological diseases; Disease modeling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Developing efficient models for neurological diseases enables us to uncover disease mechanisms and develop therapeutic strategies to treat them. Discovery of reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the way of modeling human diseases, especially neurological diseases. Currently almost all types of neural cells, including but not limited to neural stem cells, neurons, astrocytes, oligodendrocytes and microglia, can be derived from iPSCs following developmental principles. These iPSC-derived neural cells provide valuable tools for studying neurological disease mechanisms, developing potential therapies, and deepening our understanding of the nervous system.
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页码：143 / 151
页数：8
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