PET imaging of DNA damage using 89Zr-labelled anti-γH2AX-TAT immunoconjugates

[1] Helleday T(2008)DNA repair pathways as targets for cancer therapy Nat Rev Cancer 8 193-204

[2] Petermann E(2007)DNA damage signalling guards against activated oncogenes and tumour progression Oncogene 26 7773-7779

[3] Lundin C(2011)Imaging DNA damage in vivo using gammaH2AX-targeted immunoconjugates Cancer Res 71 4539-4549

[4] Hodgson B(2011)Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo Cancer Res 71 4130-4137

[5] Sharma RA(1998)DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 J Biol Chem 273 5858-5868

[6] Bartek J(2003)Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses Proc Natl Acad Sci U S A 100 5057-5062

[7] Bartkova J(2005)DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis Nature 434 864-870

[8] Lukas J(2002)Genomic instability in mice lacking histone H2AX Science 296 922-927

[9] Cornelissen B(2013)Can γH2AX be used to personalise cancer treatment? Curr Mol Med 13 1591-1602

[10] Kersemans V(2012)Amplification of DNA damage by a γH2AX-targeted radiopharmaceutical Nucl Med Biol 39 1142-1151

[1] Helleday T(2008)DNA repair pathways as targets for cancer therapy Nat Rev Cancer 8 193-204

[2] Petermann E(2007)DNA damage signalling guards against activated oncogenes and tumour progression Oncogene 26 7773-7779

[3] Lundin C(2011)Imaging DNA damage in vivo using gammaH2AX-targeted immunoconjugates Cancer Res 71 4539-4549

[4] Hodgson B(2011)Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo Cancer Res 71 4130-4137

[5] Sharma RA(1998)DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 J Biol Chem 273 5858-5868

[6] Bartek J(2003)Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses Proc Natl Acad Sci U S A 100 5057-5062

[7] Bartkova J(2005)DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis Nature 434 864-870

[8] Lukas J(2002)Genomic instability in mice lacking histone H2AX Science 296 922-927

[9] Cornelissen B(2013)Can γH2AX be used to personalise cancer treatment? Curr Mol Med 13 1591-1602

[10] Kersemans V(2012)Amplification of DNA damage by a γH2AX-targeted radiopharmaceutical Nucl Med Biol 39 1142-1151