Recent advances in the developmental origin of neuroblastoma: an overview

被引：0
作者：
Mirco Ponzoni
Tiziana Bachetti
Maria Valeria Corrias
Chiara Brignole
Fabio Pastorino
Enzo Calarco
Veronica Bensa
Elena Giusto
Isabella Ceccherini
Patrizia Perri
机构：
[1] IRCCS Istituto Giannina Gaslini,Laboratory of Experimental Therapies in Oncology
[2] IRCSS Ospedale Policlinico San Martino,U.O. Proteomica e Spettrometria di Massa
[3] IRCCS Istituto Giannina Gaslini,Laboratory of Genetics and Genomics of Rare Diseases
来源：
Journal of Experimental & Clinical Cancer Research | / 41卷
关键词：
Neural crest; Neuroblastoma; Adrenergic; Mesenchymal; Core regulatory circuitries; Transcription factors;
D O I：
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学科分类号：
摘要：
Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells undergoing a defective differentiation due to genomic and epigenetic impairments. Therefore, NB may arise at any final site reached by migrating neural crest cells (NCCs) and their progeny, preferentially in the adrenal medulla or in the para-spinal ganglia.
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