The impact of premorbid and current intellect in schizophrenia: Cognitive, symptom, and functional outcomes

被引：59

作者：

Wells R. ^{[1
,2
]}

Swaminathan V. ^{[3
,4
,5
,6
]}

Sundram S. ^{[3
,4
,5
,7
]}

Weinberg D. ^{[1
,2
]}

Bruggemann J. ^{[1
,2
]}

Jacomb I. ^{[2
]}

Cropley V. ^{[3
]}

Lenroot R. ^{[1
,2
,5
]}

Pereira A.M. ^{[3
,6
]}

Zalesky A. ^{[3
]}

Bousman C. ^{[3
]}

Pantelis C. ^{[3
,5
]}

Weickert C.S. ^{[1
,2
,5
]}

Weickert T.W. ^{[1
,2
,5
]}

机构：

[1] School of Psychiatry, University of New South Wales, Sydney, NSW

[2] Neuroscience Research Australia, Randwick, Sydney, NSW

[3] Department of Psychiatry, University of Melbourne, Parkville, VIC

[4] Northern Psychiatry Research Centre, North Western Mental Health, Melbourne Health, VIC

[5] Schizophrenia Research Institute, Sydney, NSW

[6] Molecular Psychopharmacology Laboratory, Florey Institute of Neuroscience and Mental Health, Parkville, VIC

[7] Department of Psychiatry, School of Clinical Sciences, Monash University, Clayton, VIC

来源：

npj Schizophrenia | / 1卷 / 1期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/npjschz.2015.43

中图分类号：

学科分类号：

摘要：

BACKGROUND: Cognitive heterogeneity among people with schizophrenia has been defined on the basis of premorbid and current intelligence quotient (IQ) estimates. In a relatively large, community cohort, we aimed to independently replicate and extend cognitive subtyping work by determining the extent of symptom severity and functional deficits in each group. METHODS: A total of 635 healthy controls and 534 patients with a diagnosis of schizophrenia or schizoaffective disorder were recruited through the Australian Schizophrenia Research Bank. Patients were classified into cognitive subgroups on the basis of the Wechsler Test of Adult Reading (a premorbid IQ estimate) and current overall cognitive abilities into preserved, deteriorated, and compromised groups using both clinical and empirical (k-means clustering) methods. Additional cognitive, functional, and symptom outcomes were compared among the resulting groups. RESULTS: A total of 157 patients (29%) classified as 'preserved' performed within one s.d. of control means in all cognitive domains. Patients classified as 'deteriorated' (n = 239, 44%) performed more than one s.d. below control means in all cognitive domains except estimated premorbid IQ and current visuospatial abilities. A separate 138 patients (26%), classified as 'compromised,' performed more than one s.d. below control means in all cognitive domains and displayed greater impairment than other groups on symptom and functional measures. CONCLUSIONS: In the present study, we independently replicated our previous cognitive classifications of people with schizophrenia. In addition, we extended previous work by demonstrating worse functional outcomes and symptom severity in the compromised group. © 2015 Schizophrenia International Research Society/Nature Publishing Group.

引用

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