Epidemiology, pathological characteristics and estrogen and progesterone receptor status of operated cases of female breast cancer: A retrospective review of 266 cases from Kerala

被引：2

作者：

Vettuparambil A. ^{[1
]}

Rajan G. ^{[1
]}

Chirukandath R. ^{[1
]}

Culas T.B. ^{[1
]}

机构：

[1] Government Medical College, Thrissur, 680596, Kerala

来源：

Indian Journal of Surgical Oncology | 2015年 / 6卷 / 4期

关键词：

Age; Breast cancer; Estrogen receptor; Grade; Kerala; Lymph node; Menopause; Progesterone receptor; Stage;

D O I：

10.1007/s13193-015-0425-9

中图分类号：

学科分类号：

摘要：

Breast cancer is presently the most common cancer among women in Kerala, in Southern India. The objectives of this study were to analyze the epidemiology and pathological characteristics of female breast carcinoma in Kerala. 266 patients who were diagnosed with operable breast cancer between April 2009 and June 2010 were studied. Various pathological characteristics including stage, grade, axillary lymph nodal status, tumor size, and estrogen and progesterone receptor status were studied. Estrogen and progesterone receptor status were evaluated by immunohistochemistry. Chi-square test and frequency tables were used for statistical analysis. The mean age at presentation was 50 years. 48.9 % of the patients were premenopausal. 53.76 % had grade II tumors. Positive axillary lymph nodes were found in 70.3%patients, and 68% presented with stage II disease. 54.13 % were ER positive and 62% were PR positive. The relatively young age at diagnosis, late presentation of the disease, and lower estrogen and progesterone receptor expression compared to patients from the West point toward the need for better breast cancer awareness and screening programmes in Kerala. © Indian Association of Surgical Oncology 2015.

引用

页码：352 / 355

页数：3

共 15 条

[1]

Consolidated report of the population based cancer registries.1990-1996, Indian Council of Medical Research, (2001)

[2]

Hammond M., Hayes D.F., Dowsett M., Allred D.C., Hagerty K.L., Badve S., Fitzgibbons P.L., Francis G., Goldstein N.S., Hayes M., Hicks D.G., Lester S., Love R., Mangu P.B., McShane L., Miller K., Osborne C.K., Paik S., Perlmutter J., Rhodes A., Sasano H., Schawrtz J.N., Sweep F., Taube S., Torlakovic E.E., Valenstein P., Viale G., Visscher D., Wheeler Williams R.B., Et al., ASCO-CAP guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer

[3]

Seer-Stat Database

[4]

Leong S., Shen Z.Z., Liu T.J., Agarwal G., Tajima T., Paik N., Et al., Is breast cancer the same disease in Asian and western countries?, World J Surg, 34, pp. 2308-2324, (2010)

[5]

Swanson G.M., Lin C.S., Survival pattern among younger women with breast cancer:The effects of age,race,stage and treatment, Monogr Natl Cancer Inst, 16, pp. 69-77, (1994)

[6]

El Saghir N.S., Seoud M., Khalil M.K., Et al., Effects of young age at presentation on survival in breast cancer, BMC Cancer, 16, (2006)

[7]

Sariego J., Patterns of breast cancer presentation in the United States: Does geography matter?, Am Surg, 75, pp. 545-550, (2009)

[8]

Stead L.A., Lash T.L., Sobieraj J.E., Et al., Triple negative breast cancer are increased in black women regardless of age or BMI, Breast Cancer Res, 11, (2009)

[9]

Taucher S., Rudas M., Mader R.M., Et al., Do we need Her2/neu testing for all patients with primary breast carcinoma?, Cancer, 98, pp. 2547-2553, (2003)

[10]

Saxena S., Rekhi B., Bansal A., Et al., Clinico-morphological pattern of breast cancer including family history in a New Delhi hospital,India-a cross sectional study, World J Surg Oncol, 3, (2005)

← 1 2 →