Determination of Formaldehyde in Urine by Headspace Gas Chromatography

被引：0

作者：

Akito Takeuchi

Tomoko Takigawa

Mikiko Abe

Toshio Kawai

Yoko Endo

Tomojiro Yasugi

Ginji Endo

Keiki Ogino

机构：

[1] Okayama University,Department of Public Health

[2] Graduate School of Medicine,Department of Anatomy and Cellbiology

[3] Dentistry and Pharmaceutical Sciences,Research Center for Occupational Poisoning

[4] Osaka City University Medical School,Department of Preventive Medicine and Environmental Health

[5] Osaka Occupational Health Service Center,undefined

[6] Tokyo Rosai Hospital,undefined

[7] Japan Labour Health and Welfare Organization,undefined

[8] Chugoku and Shikoku Regional Safety and Health Service Center,undefined

[9] Osaka City University Medical School,undefined

来源：

Bulletin of Environmental Contamination and Toxicology | 2007年 / 79卷

关键词：

Formaldehyde; Headspace analysis; Gas chromatography; Human urine; -(2,3,4,5,6-pentafluorobenzyl)hydroxylamine;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Formaldehyde is a carcinogen to which humans are exposed daily, but few methods are available to quantify formaldehyde in biological samples. We developed a simple, sensitive and rapid technique for the quantification of formaldehyde in urine by derivatization with O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine, using a headspace sampler coupled to a gas chromatograph equipped with an electron capture detector. The detection limit was 1.08 µg/L. The overall recovery of formaldehyde spiked in urine was 99%. The concentration of formaldehyde in urine obtained from healthy volunteers ranged from 56.85 to 144.57 µg/L. This method can be used successfully to measure formaldehyde in urine.

引用

页码：1 / 4

页数：3

共 31 条

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