Structure-guided improvement of Cas9 specificity

被引：0
|
作者：
Eytan Zlotorynski
机构：
来源：
Nature Reviews Molecular Cell Biology | 2016年 / 17卷 / 1期
关键词：
D O I：
10.1038/nrm.2015.18
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：3 / 3
相关论文
共 50 条
  • [1] A Molecule-Scale View of the Structure and Specificity of the RNA-Guided Endonuclease Cas9
    Josephs, Eric A.
    Kocak, D. Dewran
    Fitzgibbon, Christopher J.
    McMenemy, Joshua
    Gersbach, Charles A.
    Marszalek, Piotr E.
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 238A - 238A
  • [2] DNA targeting specificity of RNA-guided Cas9 nucleases
    Patrick D Hsu
    David A Scott
    Joshua A Weinstein
    F Ann Ran
    Silvana Konermann
    Vineeta Agarwala
    Yinqing Li
    Eli J Fine
    Xuebing Wu
    Ophir Shalem
    Thomas J Cradick
    Luciano A Marraffini
    Gang Bao
    Feng Zhang
    Nature Biotechnology, 2013, 31 : 827 - 832
  • [3] DNA targeting specificity of RNA-guided Cas9 nucleases
    Hsu, Patrick D.
    Scott, David A.
    Weinstein, Joshua A.
    Ran, F. Ann
    Konermann, Silvana
    Agarwala, Vineeta
    Li, Yinqing
    Fine, Eli J.
    Wu, Xuebing
    Shalem, Ophir
    Cradick, Thomas J.
    Marraffini, Luciano A.
    Bao, Gang
    Zhang, Feng
    NATURE BIOTECHNOLOGY, 2013, 31 (09) : 827 - +
  • [4] Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage
    Josephs, Eric A.
    Kocak, D. Dewran
    Fitzgibbon, Christopher J.
    McMenemy, Joshua
    Gersbach, Charles A.
    Marszalek, Piotr E.
    NUCLEIC ACIDS RESEARCH, 2015, 43 (18) : 8924 - 8941
  • [5] Targeting Specificity of Cas9 Nucleases and Tools for the Selection of High Fidelity Cas9 Targets
    Scott, David A.
    Hsu, Patrick D.
    Weinstein, Joshua A.
    Holmes, Benjamin
    Ran, F. Ann
    Zhang, Feng
    MOLECULAR THERAPY, 2014, 22 : S125 - S126
  • [6] A small molecule improves Cas9 specificity
    Rusk, Nicole
    NATURE METHODS, 2015, 12 (06) : 486 - 487
  • [7] Targeting Specificity of the CRISPR/Cas9 System
    Tasan, Ipek
    Zhao, Huimin
    ACS SYNTHETIC BIOLOGY, 2017, 6 (09): : 1609 - 1613
  • [8] A small molecule improves Cas9 specificity
    Nicole Rusk
    Nature Methods, 2015, 12 : 486 - 486
  • [9] Expanded Specificity Profiles of CRISPR/Cas9 RNA-Guided Nucleases in Human Cells
    Tsai, Shengdar Q.
    Wyvekens, Nicolas
    Foden, Jennifer A.
    Khayter, Cyd
    Cascio, Vincent M.
    Joung, J. Keith
    MOLECULAR THERAPY, 2014, 22 : S125 - S125
  • [10] Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
    Ran, F. Ann
    Hsu, Patrick D.
    Lin, Chie-Yu
    Gootenberg, Jonathan S.
    Konermann, Silvana
    Trevino, Alexandro E.
    Scott, David A.
    Inoue, Azusa
    Matoba, Shogo
    Zhang, Yi
    Zhang, Feng
    CELL, 2013, 154 (06) : 1380 - 1389
12345