Feasibility of 2-deoxy-2-[18F]fluoro-D-glucose-A85380-PET for imaging of human cardiac nicotinic acetylcholine receptors in vivo

被引：1

作者：

Bucerius J. ^{[1
]}

Joe A.Y. ^{[1
]}

Schmaljohann J. ^{[1
,3
]}

Gündisch D. ^{[2
]}

Minnerop M. ^{[3
]}

Biersack H.-J. ^{[1
]}

Wüllner U. ^{[3
]}

Reinhardt M.J. ^{[1
]}

机构：

[1] University of Bonn, Department of Nuclear Medicine, 53105 Bonn

[2] University of Bonn, Department of Pharmaceutical Chemistry, 53115 Bonn

[3] University of Bonn, Department of Neurology, 53105 Bonn

来源：

Clinical Research in Cardiology | 2006年 / 95卷 / 2期

关键词：

Human heart; Multiple system atrophy; Nicotinic acetylcholine receptors; Parkinson's disease; Positron emission tomography;

D O I：

10.1007/s00392-006-0342-6

中图分类号：

学科分类号：

摘要：

Nicotinic acetylcholine receptors mediate the parasympathetic autonomic control of cardiac function. Aim of this study was the assessment of cardiac nicotinic acetylcholine receptor distribution with a novel (α 4β2) nicotinic acetylcholine receptor PET ligand (2-deoxy-2-[18F]fluoro-D-glucose-A85380) in humans. Five healthy volunteers without cardiac disease and six patients with either Parkinson's disease or multiple system atrophy without additional overt cardiac disease were evaluated with 2-deoxy-2- [18F]fluoro-D-glucose-A85380 PET-imaging to assess the cardiac parasympathetic innervation and the putative impact of both disorders. 2-deoxy-2-[18F]fluoro-D-glucose-A85380 whole body PET-scans were performed on a Siemens PET/CT biograph™ 75.4 min ± 6.7 after i.v. injection of 371.2 ± 58.1 MBq. Average count rate density of left ventricle ROI's and a standard ROI in the right lung were measured within three consecutive slices of 10.0 mm thickness. Heart-to-lung ratios were calculated in each volunteer and patient. Tracer uptake in the left ventricle could be measured in all of the five volunteers and the six patients. Heart-to-lung ratios in the volunteer group were not different from patients suffering from Parkinson's disease or MSA (3.2 ± 0.5 vs 3.2 ± 0.8 and 2.96 ± 0.7, mean ± SD), respectively. Human cardiac nicotinic acetylcholine receptors can be visualized and measured by 2-deoxy-2-[ 18F]fluoro-D-glucose-A85380 PET scans both in cardiac-healthy subjects and patients suffering from Parkinson's disease or multiple system atrophy. The heart- as well as the lung-tracer uptake was almost constant throughout all subjects leading to a good target-to-background ratio. These first results suggest no impact of either PD or MSA on cardiac nicotinic acetylcholine receptors. © Steinkopff Verlag 2006.

引用

页码：105 / 109

页数：4

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