Nerve regeneration using the Bio 3D nerve conduit fabricated with spheroids

被引:0
作者
Ryosuke Ikeguchi
Tomoki Aoyama
Mai Tanaka
Takashi Noguchi
Maki Ando
Koichi Yoshimoto
Daichi Sakamoto
Terunobu Iwai
Yudai Miyazaki
Shizuka Akieda
Makoto Ikeya
Koichi Nakayama
Shuichi Matsuda
机构
[1] Kyoto University Graduate School of Medicine,Department of Orthopaedic Surgery
[2] Kyoto University,Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine
[3] Cyfuse Biomedical K.K.,Department of Clinical Application, Center for iPS Cell Research and Application
[4] Kyoto University,Department of Regenerative Medicine and Biomedical Engineering, Faculty of Medicine
[5] Saga University,undefined
来源
Journal of Artificial Organs | 2022年 / 25卷
关键词
Peripheral nerve; Regeneration; Bio 3D printer; Bio 3D nerve conduit; Nerve conduit;
D O I
暂无
中图分类号
学科分类号
摘要
Autologous nerve grafting is the gold standard method for peripheral nerve injury with defects. Artificial nerve conduits have been developed to prevent morbidity at the harvest site. However, the artificial conduit regeneration capacity is not sufficient. A Bio 3D printer is technology that creates three-dimensional tissue using only cells. Using this technology, a three-dimensional nerve conduit (Bio 3D nerve conduit) was created from several cell spheroids. We reported the first application of the Bio 3D nerve conduit for peripheral nerve injury. A Bio 3D nerve conduit that was created from several cells promotes peripheral nerve regeneration. The Bio 3D nerve conduit may be useful clinically to treat peripheral nerve defects.
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页码:289 / 297
页数:8
相关论文
共 252 条
[1]  
Cuevas P(2002)Peripheral nerve regeneration by bone marrow stromal cells Neurol Res 24 634-638
[2]  
Carceller F(2004)Bone marrow stromal cell implantation for peripheral nerve repair Neurol Res 26 230-232
[3]  
Dujovny M(2006)Study of in vivo differentiation of rat bone marrow stromal cells into schwann cell-like cells Microsurgery 26 111-115
[4]  
Garcia-Gómez I(2007)Transplantation of bone marrow stromal cells for peripheral nerve repair Exp Neurol 204 443-453
[5]  
Cuevas B(2007)Nerve regeneration promoted in a tube with vascularity containing bone marrow-derived cells Cell Transplant 16 811-822
[6]  
González-Corrochano R(2008)Bridging small-gap peripheral nerve defects using acellular nerve allograft implanted with autologous bone marrow stromal cells in primates Brain Res 1188 44-53
[7]  
Diaz-González D(2010)Isogenic venous graft supported with bone marrow stromal cells as a natural conduit for bridging a 20 mm nerve gap Microsurgery 30 639-645
[8]  
Reimers D(2010)Use of tissue-engineered nerve grafts consisting of a chitosan/poly (lactic-co-glycolic acid)-based scaffold included with bone marrow mesenchymal cells for bridging 50-mm dog sciatic nerve gaps Tissue Eng Part A 16 3779-3790
[9]  
Cuevas P(2011)Peripheral nerve defect repair with epineural tubes supported with bone marrow stromal cells: a preliminary report Ann Plast Surg 67 73-84
[10]  
Carceller F(2011)A systematic evaluation of Schwann cell injection into acellular cold-preserved nerve grafts J Neurosci Methods 197 209-215