Lidocaine pretreatment attenuates inflammatory response and protects against sepsis-induced acute lung injury via inhibiting potassium efflux-dependent NLRP3 activation

[1] Iscimen R(2008)Risk factors for the development of acute lung injury in patients with septic shock: an observational cohort study Crit Care Med 36 1518-1522

[2] Cartin-Ceba R(1985)Functional pathophysiology of SARS-CoV-2-induced acute lung injury and clinical implications J Appl Physiol 2021 877-891

[3] Yilmaz M(2003)Incidence of acute lung injury in the United States Crit Care Med 31 1607-1611

[4] Khan H(2021)Cell–cell interaction mechanisms in acute lung injury Shock 55 167-176

[5] Hubmayr RD(2018)Regulation of alveolar macrophage death in acute lung inflammation Respir Res 19 50-1153

[6] Afessa B(2013)K Immunity 38 1142-349

[7] Gajic O(2018) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter Immunity 49 335-1170

[8] Habashi NM(2019)The TWIK2 potassium efflux channel in macrophages mediates NLRP3 inflammasome-induced inflammation Br J Anaesth 123 1165-10971

[9] Camporota L(1999)Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review Anesthesiology 90 10964-100

[10] Gatto LA(2019)Differential effects of lidocaine and mexiletine on relaxations to ATP-sensitive K+ channel openers in rat aortas J Cell Biochem 120 94-37132

[1] Iscimen R(2008)Risk factors for the development of acute lung injury in patients with septic shock: an observational cohort study Crit Care Med 36 1518-1522

[2] Cartin-Ceba R(1985)Functional pathophysiology of SARS-CoV-2-induced acute lung injury and clinical implications J Appl Physiol 2021 877-891

[3] Yilmaz M(2003)Incidence of acute lung injury in the United States Crit Care Med 31 1607-1611

[4] Khan H(2021)Cell–cell interaction mechanisms in acute lung injury Shock 55 167-176

[5] Hubmayr RD(2018)Regulation of alveolar macrophage death in acute lung inflammation Respir Res 19 50-1153

[6] Afessa B(2013)K Immunity 38 1142-349

[7] Gajic O(2018) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter Immunity 49 335-1170

[8] Habashi NM(2019)The TWIK2 potassium efflux channel in macrophages mediates NLRP3 inflammasome-induced inflammation Br J Anaesth 123 1165-10971

[9] Camporota L(1999)Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review Anesthesiology 90 10964-100

[10] Gatto LA(2019)Differential effects of lidocaine and mexiletine on relaxations to ATP-sensitive K+ channel openers in rat aortas J Cell Biochem 120 94-37132