miR-24 affects hair follicle morphogenesis targeting Tcf-3

被引：0
作者：
I Amelio
A M Lena
E Bonanno
G Melino
E Candi
机构：
[1] Medical Research Council,Department of Experimental Medicine and Biochemical Sciences
[2] Toxicology Unit,undefined
[3] Leicester University,undefined
[4] Biochemistry Laboratory IDI-IRCCS and University of Rome ‘Tor Vergata’,undefined
[5] Department of Biopathology and Image Diagnostics,undefined
来源：
Cell Death & Disease | 2013年 / 4卷
关键词：
microRNA; miR-24; hair follicle; skin; Tcf-3; stem cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
During embryonic development, hair follicles (HFs) develop from an epidermal–mesenchymal cross talk between the ectoderm progenitor layer and the underlying dermis. Epidermal stem cell activation represents a crucial point both for HF morphogenesis and for hair regeneration. miR-24 is an anti-proliferative microRNA (miRNA), which is induced during differentiation of several cellular systems including the epidermis. Here, we show that miR-24 is expressed in the HF and has a role in hair morphogenesis. We generated transgenic mice ectopically expressing miR-24 under the K5 promoter. The K5::miR-24 animals display a marked defect in HF morphogenesis, with thinning of hair coat and altered HF structure. Expression of miR-24 alters the normal process of hair keratinocyte differentiation, leading to altered expression of differentiation markers. MiR-24 directly represses the hair keratinocyte stemness regulator Tcf-3. These results support the notion that microRNAs, and among them miR-24, have an important role in postnatal epidermal homeostasis.
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页码：e922 / e922
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