Effect of maternal gestational weight gain on offspring DNA methylation: a follow-up to the ALSPAC cohort study

被引：8

作者：

Bohlin J. ^{[1
]}

Andreassen B.K. ^{[1
,2
]}

Joubert B.R. ^{[3
]}

Magnus M.C. ^{[1
]}

Wu M.C. ^{[4
]}

Parr C.L. ^{[1
]}

Håberg S.E. ^{[1
]}

Magnus P. ^{[1
]}

Reese S.E. ^{[3
]}

Stoltenberg C. ^{[1
]}

London S.J. ^{[3
]}

Nystad W. ^{[1
]}

机构：

[1] Division of Epidemiology, Norwegian Institute of Public Health, Marcus Thranes gate 6, P.O. Box 4404, Oslo

[2] Department of Molecular Biology, Institute of Clinical Medicine, University of Oslo, Oslo

[3] National Institute of Environmental Health Sciences, MD A3-05, PO Box 12233, Research Triangle Park, 27709, NC

[4] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, 98109, WA

来源：

BMC Research Notes | / 8卷 / 1期

关键词：

Gestational Weight Gain; Infinium HumanMethylation450 BeadChip; Child Cohort Study; Cell Type Proportion; Genomic Inflation Factor;

D O I：

10.1186/s13104-015-1286-6

中图分类号：

学科分类号：

摘要：

Background: Several epidemiologic studies indicate that maternal gestational weight gain (GWG) influences health outcomes in offspring. Any underlying mechanisms have, however, not been established. A recent study of 88 children based on the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort examined the methylation levels at 1,505 Cytosine-Guanine methylation (CpG) loci and found several to be significantly associated with maternal weight gain between weeks 0 and 18 of gestation. Since these results could not be replicated we wanted to examine associations between 0 and 18 week GWG and genome-wide methylation levels using the Infinium HumanMethylation450 BeadChip (450K) platform on a larger sample size, i.e. 729 newborns sampled from the Norwegian Mother and Child Cohort Study (MoBa). Results: We found no CpG loci associated with 0-18 week GWG after adjusting for the set of covariates used in the ALSPAC study (i.e. child's sex and maternal age) and for multiple testing (q > 0.9, both 1,505 and 473,731 tests). Hence, none of the CpG loci linked with the genes found significantly associated with 0-18 week GWG in the ALSPAC study were significant in our study. Conclusions: The inconsistency in the results with the ALSPAC study with regards to the 0-18 week GWG model may arise for several reasons: sampling from different populations, dissimilar methylome coverage, sample size and/or false positive findings. © 2015 Bohlin et al.

引用

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