Association of GABRA2 with Drug Dependence in the Collaborative Study of the Genetics of Alcoholism Sample

被引：0
作者：
Arpana Agrawal
Howard J. Edenberg
Tatiana Foroud
Laura J. Bierut
Gerald Dunne
Anthony L. Hinrichs
John I. Nurnberger
Raymond Crowe
Samuel Kuperman
Marc A. Schuckit
Henri Begleiter
Bernice Porjesz
Danielle M. Dick
机构：
[1] Washington University in St. Louis,Department of Psychiatry
[2] Indiana University School of Medicine,Department of Psychiatry
[3] University of Iowa,undefined
[4] University of California–San Diego,undefined
[5] State University of New York,undefined
[6] Washington University in St. Louis,undefined
来源：
Behavior Genetics | 2006年 / 36卷
关键词：
Alcoholism; association analyses; COGA; drug dependence; GABRA2; PDT;
D O I：
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学科分类号：
摘要：
Results from twin studies suggest that overlapping genetic factors influence alcohol dependence and illicit drug dependence. Using data from the Collaborative Study on the Genetics of Alcoholism (COGA), we examined the association between 69 SNPs in the GABAA receptor gene cluster on chromosome 4 and marijuana and illicit drug dependence, individually, and as co-occurring phenotypes with alcohol dependence. Results suggested association between marijuana dependence and illicit drug dependence with SNPs in the GABRA2 gene. Interestingly, the evidence for association previously observed with alcohol dependence came only from individuals with comorbid illicit drug dependence. There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence.
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页码：640 / 650
页数：10
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