Updates in biological therapies for knee injuries: Anterior cruciate ligament

被引：13

作者：

Da Silveira Franciozi C.E. ^{[1
,2
]}

Ingham S.J.M. ^{[1
,2
]}

Gracitelli G.C. ^{[1
]}

Luzo M.V.M. ^{[1
]}

Fu F.H. ^{[3
]}

Abdalla R.J. ^{[1
,2
]}

机构：

[1] Department of Orthopaedic Surgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, Vila Clementino, 04038-032 São Paulo, SP, Rua Borges Lagoa

[2] Knee Institute, Hospital Do Coração, São Paulo, SP

[3] Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213

来源：

Current Reviews in Musculoskeletal Medicine | 2014年 / 7卷 / 3期

关键词：

Arthroscopy; Augmentation; Biological; Classification; Growth factor; Healing; Knee/anterior cruciate ligament; Mechanical stimuli; Mesenchymal stem cell; Partial lesion; Platelet rich plasma; Preservation; Reconstruction; Remnant; Repair; Scaffold; Tissue engineering; Treatment;

D O I：

10.1007/s12178-014-9228-9

中图分类号：

学科分类号：

摘要：

There have been many advances in anterior cruciate ligament reconstruction (ACLR) techniques incorporating biological treatment. The aim of this review is to discuss the recent contributions that may enlighten our understanding of biological therapies for anterior cruciate ligament (ACL) injuries and improve management decisions involving these enhancement options. Three main biological procedures will be analyzed: bio-enhanced ACL repair, bio-enhanced ACLR scrutinized under the four basic principles of tissue engineering (scaffolds, cell sources, growth factors/cytokines including platelet-rich plasma, and mechanical stimuli), and remnant-preserving ACLR. There is controversial information regarding remnant-preserving ACLR, since different procedures are grouped under the same designation. A new definition for remnant-preserving ACLR surgery is proposed, dividing it into its three major procedures (selective bundle augmentation, augmentation, and nonfunctional remnant preservation); also, an ACL lesion pattern classification and a treatment algorithm, which will hopefully standardize these terms and procedures for future studies, are presented. © 2014 Springer Science+Business Media.

引用

页码：228 / 238

页数：10

共 70 条

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