The role of complement in antibody-mediated rejection in kidney transplantation

被引：0
作者：
Mark D. Stegall
Marcio F. Chedid
Lynn D. Cornell
机构：
[1] Department of Surgery,
[2] Division of Transplantation Surgery and von Liebig Transplant Center,undefined
[3] Department of Laboratory Medicine and Pathology,undefined
[4] Division of Anatomic Pathology,undefined
来源：
Nature Reviews Nephrology | 2012年 / 8卷
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摘要：
Much progress has been made in understanding the processes underlying antibody-mediated rejection (AMR) of transplanted organs. In this Review, the authors discuss the role of the complement system in acute and chronic AMR, with specific emphasis on renal transplantation, and describe studies demonstrating that blockade of terminal complement activation can prevent AMR in sensitized renal transplant recipients.
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页码：670 / 678
页数：8
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