Potential phytochemicals in the prevention and treatment of esophagus cancer: A green therapeutic approach

被引：0
作者：
Banzeer Ahsan Abbasi
Javed Iqbal
Riaz Ahmad
Sitara Bibi
Tariq Mahmood
Sobia Kanwal
Sheeza Bashir
Farhat Gul
Safia Hameed
机构：
[1] Quaid-i-Azam University,Department of Plant Sciences
[2] Shaanxi Normal University,College of Life Sciences
[3] University of Gujrat,Department of Zoology
[4] Quaid-i-Azam University,Department of Biotechnology
来源：
Pharmacological Reports | 2019年 / 71卷
关键词：
Esophagus cancer; Phytochemicals; Anticancer drugs; Chemotherapy; Radiation therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Globally, esophagus cancer (EC) is one of the most frequently reported malignancies and leading cause of deaths. Currently, different treatment methods are available like chemotherapy, radiation therapy, surgery or their combination. These treatment strategies are not enough and are often associated with adverse side effects. The alternate treatment option like phytochemicals have come up with ease of bioavailability and cost-effectiveness. Due to general acceptance, lower side effects, safety and pleiotropic effect, phytochemicals can be used as an adjuvant treatment for alleviating side effects associated with chemotherapy and radiotherapy. Phytochemicals perform multiple functions; release cytochrome-c, loss mitochondrial membrane potential, down-regulate expression of anti-apoptotic proteins, up-regulate pro-apoptotic proteins, activate caspases, p53, inhibit Akt/mTOR signaling pathway, phosphorylate NF-κB, STAT3 and PI3K. The knowledge compiled here encompasses anti-EC phytochemicals, their occurrence, bioavailability therapeutic effects and mechanism of action by targeting several genes and signaling pathways. Overall, the clinical data compiled on phytochemicals against EC is not sufficient and need future research to provide additional insights for developing potential anticancer drugs in pharma industries.
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页码：644 / 652
页数：8
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  • [21] Jemal MPH(2010)Dietary factors and the risks of oesophageal adenocarcinoma and Barrett’s oesophagus Nutr Res Rev 23 230-21
  • [22] Pennathur A(2000)Influence of mate drinking, hot beverages and diet on esophageal cancer risk in South America Int J Cancer 88 658-38
  • [23] Gibson MK(2004)Risk factors for esophageal cancer in Coimbatore, southern India: a hospital-based case-control study Indian J Gastroenterol 23 19-12
  • [24] Jobe BA(2013)Sinomenine hydrochloride inhibits human hepatocellular carcinoma cell growth in vitro and in vivo: involvement of cell cycle arrest and apoptosis induction Int J Oncol 42 229-6
  • [25] Luketich JD(2005)The anti-angiogenic effect of sinomenine Angiogenesis 8 3-300
  • [26] Mao WM(2010)Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro Mol Med Rep 3 51-4
  • [27] Zheng WH(2013)Cooperative inhibitory effect of sinomenine combined with 5-fluorouracil on esophageal carcinoma World J Gastroenterol WJG19 8292-55
  • [28] Ling ZQ(2008)Qinghaosu (artemisinin): the price of success Science 320 330-8
  • [29] Mir MM(2015)Artesunate altered cellular mechanical properties leading to deregulation of cell proliferation and migration in esophageal squamous cell carcinoma Oncol Lett 9 2249-54
  • [30] Dar NA(2000)Chromosomal instability and cytoskeletal defects in oral cancer cells Proc Natl Acad Sci USA 97 303-13
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