Severe hypoglycemia in a patient with anorexia nervosa

被引：0
作者：
Yanai H. [1 ,4 ]
Yoshida H. [2 ]
Tomono Y. [3 ]
Tada N. [1 ]
机构：
[1] Department of Internal Medicine, Jikei University School of Medicine, Chiba
[2] Department of Laboratory Medicine, Jikei University School of Medicine, Chiba
[3] Department of Nutrition, Jikei University School of Medicine, Chiba
[4] Department of Internal Medicine, Kashiwa Hospital, Jikei University School of Medicine, Kashiwa, Chiba 277-8567
来源：
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity | 2008年 / 13卷 / 1期
关键词：
Glucagons; Glucose-dependent insulinotropic polypeptide; Hypoglycemia; Insulin;
D O I：
10.1007/BF03327785
中图分类号：
学科分类号：
摘要：
OBJECTIVE: Severe hypoglycemia is an important but uncommon complication of anorexia nervosa. A 35-year-old woman showed severe hypoglycemia after a recovery from severe liver dysfunction due to malnutrition. METHODS: To reveal the cause of severe hypoglycemia, we measured plasma hormones and performed a 75g oral glucose loading test. RESULTS: Fasting serum adrenocorticotropic hormone, cortisol, growth hormone, somatostatin, and active ghrelin were elevated. Serum free triiodothyronine, leptin, and adiponectin were reduced. Plasma glucose fluctuated from 67 to 76 mg/dl after a 75g glucose ingestion, without hyperinsulinemia. Serum growth hormone, somatostatin, and active ghrelin levels were decreased after glucose ingestion. Plasma glucagon levels were increased and remained at high levels at 120 min, and glucose-dependent insulinotropic polypeptide (GIP) levels were continuously and remarkably increased after glucose ingestion. CONCLUSION: We observed a strongly reduced sensitivity in glucagon-induced hepatic glycogenolysis, and significantly elevated fasting and postprandial GIP levels, and a defective GIP-mediated glucagon secretion, in an anorectic patient with severe hypoglycemia. ©2008, Editrice Kurtis.
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页码：e1 / e3
页数：2
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