Association of FTO, KCNJ11, SLC30A8, and CDKN2B polymorphisms with type 2 diabetes mellitus

被引：0
|
作者：
A. G. Nikitin
V. A. Potapov
A. N. Brovkin
E. Yu. Lavrikova
D. S. Khodyrev
M. Sh. Shamhalova
S. A. Smetanina
L. N. Suplotova
M. V. Shestakova
V. V. Nosikov
A. V. Averyanov
机构：
[1] Federal Medico-Biological Agency of Russia,Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies
[2] Arkhimed Clinics of New Medical Technologies,undefined
[3] Endocrinology Research Center,undefined
[4] Tyumen State Medical Academy,undefined
来源：
Molecular Biology | 2015年 / 49卷
关键词：
type 2 diabetes mellitus; polymorphism; genetic predisposition;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
To test FTO, KCNJ11, SLC30A8, and CDKN2B for association with type 2 diabetes mellitus (DM), the allele and genotype frequency distributions were established for several polymorphisms of the genes. A comparison of allele and genotype frequencies between DM patients and healthy subjects implicated CKNJ11, SLC30A8, and CDKN2B, but not FTO, in the disease. The genes that affect insulin production and secretion in pancreatic β cells proved to play a main role in type 2 DM in the Russian population.
引用
收藏
页码：103 / 111
页数：8
相关论文
共 50 条
  • [41] Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population
    Bazzi, M. D.
    Nasr, F. A.
    Alanazi, M. S.
    Alamri, A.
    Turjoman, A. A.
    Moustafa, A. S.
    Alfadda, A. A.
    Pathan, A. A. K.
    Parine, N. R.
    GENETICS AND MOLECULAR RESEARCH, 2014, 13 (04): : 10194 - 10203
  • [42] CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients
    Klen, Jasna
    Dolzan, Vita
    Janez, Andrej
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 70 (04) : 421 - 428
  • [43] No detectable association of IGF2BP2 and SLC30A8 genes with type 2 diabetes in the population of Hyderabad, India
    Kommoju, Uma Jyothi
    Maruda, Jayaraj
    Kadarkarai, Subburaj
    Irgam, Kumuda
    Kotla, Jaya Prasad
    Velaga, Lakshmi
    Reddy, Battini Mohan
    META GENE, 2013, 1 : 15 - 23
  • [44] Correlation between KCNQ1 and KCNJ11 gene polymorphisms and type 2 and posttransplant diabetes mellitus in the Asian Indian population
    Khan, Imran Ali
    Vattam, Kiran Kumar
    Jahan, Parveen
    Mukkavali, Kamal Kiran
    Hasan, Qurratulain
    Rao, Pragna
    GENES & DISEASES, 2015, 2 (03) : 276 - 282
  • [45] Association between KCNJ11 Gene Polymorphisms and Risk of Type 2 Diabetes Mellitus in East Asian Population: A Meta-Analysis in 42, 573 Individuals
    Yang, Lijuan
    Zhou, Xianghai
    Luo, Yingying
    Sun, Xiuqin
    Tang, Yong
    Guo, Wulan
    Han, Xueyao
    Ji, Linong
    DIABETES, 2011, 60 : A665 - A665
  • [46] SLC30A8 (ZnT8) variations and type 2 diabetes in the Chinese Han population
    Xu, J.
    Wang, J.
    Chen, B.
    GENETICS AND MOLECULAR RESEARCH, 2012, 11 (02) : 1592 - 1598
  • [47] CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients
    Jasna Klen
    Vita Dolžan
    Andrej Janež
    European Journal of Clinical Pharmacology, 2014, 70 : 421 - 428
  • [48] Identifying the association between single nucleotide polymorphisms in KCNQ1, ARAP1, and KCNJ11 and type 2 diabetes mellitus in a Chinese population
    Li, Yiping
    Shen, Keyu
    Li, Chuanyin
    Yang, Ying
    Yang, Man
    Tao, Wenyu
    He, Siqi
    Shi, Li
    Yao, Yufeng
    INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2020, 17 (15): : 2379 - 2386
  • [49] Independent case-control study in KCNJ11 gene polymorphism with Type 2 diabetes Mellitus
    Alqadri, Nada
    SAUDI JOURNAL OF BIOLOGICAL SCIENCES, 2022, 29 (04) : 2794 - 2799
  • [50] Screening of KCNJ11 Mutation in Shanghai Type 2 Diabetes Mellitus With Poor Beta Cell Function
    Zhang, Rong
    Hu, Cheng
    Bao, Yuqian
    Xiang, Kunsan
    Jia, Weiping
    DIABETES, 2013, 62 : A717 - A717
12345