Association of FTO, KCNJ11, SLC30A8, and CDKN2B polymorphisms with type 2 diabetes mellitus

被引：0
|
作者：
A. G. Nikitin
V. A. Potapov
A. N. Brovkin
E. Yu. Lavrikova
D. S. Khodyrev
M. Sh. Shamhalova
S. A. Smetanina
L. N. Suplotova
M. V. Shestakova
V. V. Nosikov
A. V. Averyanov
机构：
[1] Federal Medico-Biological Agency of Russia,Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies
[2] Arkhimed Clinics of New Medical Technologies,undefined
[3] Endocrinology Research Center,undefined
[4] Tyumen State Medical Academy,undefined
来源：
Molecular Biology | 2015年 / 49卷
关键词：
type 2 diabetes mellitus; polymorphism; genetic predisposition;
D O I：
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中图分类号：
学科分类号：
摘要：
To test FTO, KCNJ11, SLC30A8, and CDKN2B for association with type 2 diabetes mellitus (DM), the allele and genotype frequency distributions were established for several polymorphisms of the genes. A comparison of allele and genotype frequencies between DM patients and healthy subjects implicated CKNJ11, SLC30A8, and CDKN2B, but not FTO, in the disease. The genes that affect insulin production and secretion in pancreatic β cells proved to play a main role in type 2 DM in the Russian population.
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页码：103 / 111
页数：8
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